Results 141 to 150 of about 1,619,987 (346)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Closing the gap in the clinical adoption of computational pathology: a standardized, open-source framework to integrate deep-learning models into the laboratory information system [PDF]

Miriam Angeloni, Davide Rizzi, Simon Schoen, Alessandro Caputo, Francesco Merolla, Arndt Hartmann, Fulvia Ferrazzi, Filippo Fraggetta   +7 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Intuitive web tools for reference interval estimation: goCrunch and ReferenceRangeR

Journal of Laboratory Medicine
Verification of reference intervals (RIs) is mandatory for clinical laboratories. In this context indirect methods of RI estimation may be of assistance, yet these are often limited to experts with programming or statistical skills due to the lack of ...
Arslan Fatma Demet, Farrell Christopher-John Lancaster, Brandhorst Gunnar, Voss Maike, Yazıcı Güvercin Ayşe Canan   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Quality improvement of outpatient clinical chemistry tests through a novel middleware-laboratory information system solution

, 2023
Minwoo Park, Young-Jin Kim, Da‐Woon Jung, Yeongsic Kim, H. Mike Kim, Youjin Lee, In Young Choi   +6 more
openalex   +1 more source

Laboratory information management system for COVID-19 non-clinical efficacy trial data [PDF]

, 2022
Suhyeon Yoon, Hyuna Noh, Heejin Jin, Sungyoung Lee, Soyul Han, Sunghee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Joon‐Yong Bae, Gee Eun Lee, Sun‐Je Woo, Sun-Min Seo, Na-Won Kim, Youn Woo Lee, Hui Jeong Jang, Seung-Min Hong, Se-Hee An, Kwang‐Soo Lyoo, Minjoo Yeom, Hanbyeul Lee, Bud Jung, Sun‐Woo Yoon, Jung‐Ah Kang, Sang‐Hyuk Seok, Y.-J. Lee, Seo Yeon Kim, Young Been Kim, Ji-Yeon Hwang, Dain On, Sooyeon Lim, Sol Pin Kim, Ji Yun Jang, Ho Lee, Kyoungmi Kim, Hyo‐Jung Lee, Hong Bin Kim, Jun Won Park, Dae Gwin Jeong, Daesub Song, Kang-Seuk Choi, Ho‐Young Lee, Yang‐Kyu Choi, Jung-ah Choi, Manki Song, Man‐Seong Park, Jun-Young Seo, Ki Taek Nam, Jeon‐Soo Shin, Sungho Won, Jun-Won Yun, Je Kyung Seong   +53 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Laboratory Data Connectivity and Management: the Intersection of Laboratory Information Management Systems, Ancillary Open-Source Software, and Consumer Technologies.

The Journal of Applied Laboratory Medicine, 2017
Nicole V. Tolan
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source