Results 161 to 170 of about 1,619,987 (346)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Data migration, validation and implementation of a new laboratory information system (LIS) in an academic pathology department, using Ellkay data archive, and Epic Beaker anatomic and clinical pathology modules

J. T. Benitez, A Erdo an, André L. M. Santos, Anthime Flaus, Matt Wawrzyszko, Beverley Young, Eleanor Latta, Catherine Streutker, Ju‐Yoon Yoon   +8 more
openalex   +1 more source

EXPERIENCE CREATION AND IMPLEMENTATION OF LABORATORY INFORMATION SYSTEMS IN THE PRACTICE CLINICAL DIAGNOSTIC LABORATORIES THE MULTIDISCIPLINARY DEPARTMENTAL MEDICAL CENTERS

, 2017
B. G. Andryukov, I. B. Andryukov, Eric Gelman, V. G. Larichev, T. V. Loginova, I. N. Fedoseevа   +5 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Digital Infrastructure for Antimicrobial Susceptibility Testing and Surveillance: A CLSI and EUCAST-Based Model for Resource-Limited Settings. [PDF]

JMIR Form Res
Mbarushimana D, Adegboyega TT, Jean Damascene G, Bale MI, Damascene BJ, Marie Francoise K, Innocent I, Alexis R, Adeyemo RO, Issa B, Akinola SA, Adedeji AA, Evariste M, Albert B, Felicite M, Sylvain H, Habarugira F, Sinumvayo JP, Noel R, Theogene T, Jules NM, Christian N.   +21 more
europepmc   +1 more source

Rapid Application Development (RAD) Method for Developing Clinical Laboratory Information System (case Study: PT. Populer Sarana Medika)

, 2018
Fardanto Setyatama, Irwan Kurnia Andrianto   +1 more
openalex   +2 more sources

Leaf LIMS: A Flexible Laboratory Information Management System with a Synthetic Biology Focus.

ACS Synthetic Biology, 2017
Thomas Craig, Richard C. G. Holland, Rosalinda D'Amore, James R. Johnson, Hannah V. McCue, A. West, Valentin Zulkower, H. Tekotte, Yizhi Cai, Daniel Swan, Robert P. Davey, C. Hertz-Fowler, Anthony Hall, M. Caddick   +13 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Intelligent technology-driven diabetes prevention and control: From informatization management to artificial intelligence. [PDF]

Sci Prog
Deng G, Chengshi W.
europepmc   +1 more source