Results 81 to 90 of about 1,157,477 (291)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Clinical and Hematological Manifestation of Dengue Patients in 2022 Outbreak: A Tertiary Care Hospital‐Based Cross‐Sectional Study

Health Science Reports
Background and Aims Dengue is a mosquito‐borne viral disease that frequently causes seasonal outbreaks in Bangladesh, particularly during the monsoon months from June to September. Recent outbreaks have shown significant shifts in clinical manifestations,
Md. Jubayer Hossain, Manisha Das, Muhibullah Shahjahan, Md. Wahidul Islam, Syeda Tasneem Towhid   +4 more
doaj   +1 more source

Immunity and central nervous system (CNS) chronic acquired toxoplasmosis

Annals of Mechnikov's Institute, 2020
When chronic acquired toxoplasmosis (САT) the regularities of changes in the ratio of the immune system (CD3, IRI, total immunoglobulins) and the functional state of the central nervous system (EEG changes on stem-diencephalic type) available informative
K Bodnya, O Bobrova, S Kotsyna, I Vernigora   +3 more
doaj  

Disruptions from a Traumatic Event: A Clinical Vignette [PDF]

, 2012
The paper presents a clinical vignette regarding the psychological assessment of a seven years old boy, following a traumatic event, an accident with a bus that resulted in his grandfather’s death.
Campos, Rui C.
core  

Apeced in Turkey: a case report and insights on genetic and phenotypic variability [PDF]

, 2018
APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune ...
Alessandra Fierabraccia, Corrado Betterle, FRASCA, FEDERICA, Marsha Pellegrino, Sara Sebnem Kilic   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Investigation of the Clinical Manifestations of COVID-19 in Critically Ill Children Admitted to the Pediatric Intensive Care Unit of Firouzabadi Hospital in 2020-2021

Archives of Anesthesia and Critical Care
Background: Considering the epidemiological importance of COVID-19 disease, the high percentage of hospitalization, and the need to prevent morbimortality caused by this disease in children, this study was undertaken to determine the clinical ...
Maryam Vafapour, Fatemeh Naderipour, Seyede Hamideh Hashemiyazdi, Ramin Zare Mahmoudabadi, Kimia Jazi, Javad Hoseinzade, Soheila Mahdavynia, Masoud Zangi   +7 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMMUNITY AND CENTRAL NERVOUS SYSTEM (CNS) CHRONIC ACQUIRED TOXOPLASMOSIS [PDF]

Annals of Mechnikov's Institute, 2014
When chronic acquired toxoplasmosis (САT) the regularities of changes in the ratio of the immune system (CD3, IRI, total immunoglobulins) and the functional state of the central nervous system (EEG changes on stem-diencephalic type) available informative
Bodnya K.I., , Bobrova O.V., Kotsyna S.S., Vernigora I.I.   +3 more
doaj  

Effects of rituximab-based B-cell depletion therapy on skin manifestations of lupus erythematosus--report of 17 cases and review of the literature [PDF]

, 2013
Cutaneous manifestations occur frequently in systemic lupus erythematosus (SLE) and are pathognomonic in subacute-cutaneous lupus erythematosus (SCLE) and chronic cutaneous lupus erythematosus (CCLE).
Hofmann, SC, Isenberg, DA, Leandro, MJ, Morris, SD   +3 more
core   +1 more source