Results 271 to 280 of about 17,654,627 (326)

Clinical Medicine [PDF]

, 2006
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A Literature Review of the Integration of Ancient Indian Mythology in Clinical Medicine: A Holistic Approach to Health and Healing. [PDF]

Cureus
Pondomatti SC, Tyagi I, Shrivastava KK, Mahajan S, Patel J, Shinde MA.   +5 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

The human vaginal microbiota: from clinical medicine to models to mechanisms. [PDF]

Curr Opin Microbiol
Ottinger S, Robertson CM, Branthoover H, Patras KA.   +3 more
europepmc   +1 more source

Embracing the digital transformation in healthcare: insights and reflections from the Korean Society of Digital Clinical Medicine Summer Conference 2024. [PDF]

Ewha Med J
Lee Y.
europepmc   +1 more source

Performance of ChatGPT on the Chinese Postgraduate Examination for Clinical Medicine: Survey Study.

JMIR Med Educ
Yu P, Fang C, Liu X, Fu W, Ling J, Yan Z, Jiang Y, Cao Z, Wu M, Chen Z, Zhu W, Zhang Y, Abudukeremu A, Wang Y, Liu X, Wang J.   +15 more
europepmc   +1 more source

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Aerospace Medicine Clinic

Aerospace Medicine and Human Performance, 2021
Kreykes AJ, Vardiman J. Aerospace medicine clinic: aseptic meningitis. Aerosp Med Hum Perform. 2021; 92(10):845848.
Geoffrey, Garst M D M P H, And Rachel, Asuquo   +1 more
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Clinical management of metastatic colorectal cancer in the era of precision medicine

Ca-A Cancer Journal for Clinicians, 2022
Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second most common cause of cancer deaths. Initial clinical presentation as metastatic CRC (mCRC) occurs in approximately 20% of patients. Moreover, up to 50% of patients with
, Davide Ciardiello, Giulia Martini
exaly   +2 more sources