Results 71 to 80 of about 934,276 (285)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Factors associated with attitudes toward research MRI in older Asian Americans

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION South Asian (SA) and East Asian (EA) older adults represent the fastest‐growing racial/ethnic groups of Americans at risk for dementia. While recruiting older SA adults into a brain health study, we encountered unexpected hesitancy toward ...
Karthik J Kota, Alice Dawson, Julia Papas, Victor Sotelo, Guibin Su, Mei‐Ling Li, Woowon Lee, Jaunis Estervil, Melissa Marquez, Shromona Sarkar, Lisa Lanza Lopez, William T. Hu   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nomogram to predict 1-year cognitive decline after stent placement for unruptured intracranial aneurysms

iScience
Summary: New iatrogenic cerebral infarcts (NICIs) are common findings on diffusion-weighted magnetic resonance imaging (DWI) following stent placement for unruptured intracranial aneurysms (UIAs) and may contribute to cognitive decline (CD).
Wenqiang Li, Chao Wang, Yuzhao Lu, Junfan Chen, Wenbin Li, Yunpeng Liu, Ziqing Zhang, Zeping Jin, Yiqi Liu, Song Tan, Zhiwei Zhang, Xiaofei Huang, Cong Ding, Linfeng Zhang, Jian Liu, David M. Hasan, Yang Wang   +16 more
doaj   +1 more source

What contributes to depression in Parkinson's disease? [PDF]

, 2001
Background: Depression is a common problem in patients with Parkinson's disease, but its mechanism is poorly understood. It is thought that neurochemical changes contribute to its occurrence, but it is unclear why some patients develop depression and ...
Jahanshahi, M., Quinn, N.P., Schrag, A.
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Clinical trial publication trends within neurology

Translational Neuroscience, 2019
Timely dissemination of results from clinical studies is crucial for the advancement of knowledge and clinical decision making. A large body of research has shown that up to half of clinical trials do not publish their findings.
Q. Duy Phan, Sreekrishnan Anirudh, David Wyatt, Paranjpe Manish D., Paranjpe Ishan, Sheth Amar, Gültekin Batur, Sheth Kevin N.   +7 more
doaj   +1 more source

Mini-CEX Sebagai Metode Penilaian Keterampilan Klinis Mahasiswa Program Pendidikan Kepaniteraan Klinik Fakultas Kedokteran Universitas Gadjah Mada - Studi Pendahuluan

Jurnal Pendidikan Kedokteran Indonesia, 2012
Background: Mini-CEX was developed to assess clinical skills by direct observation. Mini-CEX as a clinical skills assessment tool had to fulfill four requirements: validity, reliability, effects on students, and practicality. The purpose of this study is
Reza M. Munandar, Yoyo Suhoyo, Tridjoko Hadianto   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Medical students’ experience of emotions and success in neurological studies – What do they tell us?

BMC Medical Education, 2017
Background There is a need to develop effective educational experience in neurology to improve the students’ skills in diagnosing and managing patients with neurological symptoms or disease.
Hanna Ansakorpi, Marja-Liisa Sumelahti, Raimo Kaasila   +2 more
doaj   +1 more source