Results 201 to 210 of about 1,464,129 (347)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Large language model trained on clinical oncology data predicts cancer progression. [PDF]

NPJ Digit Med
Zhu M, Lin H, Jiang J, Jinia AJ, Jee J, Pichotta K, Waters M, Rose D, Schultz N, Chalise S, Valleru L, Morin O, Moran J, Deasy JO, Pilai S, Nichols C, Riely G, Braunstein LZ, Li A.   +18 more
europepmc   +1 more source

Integration of geriatric principles into clinical oncology practice: A scoping review

, 2018
George N. Okoli, Morgan Stirling, Ahmed M Abou-Setta, David E. Dawe   +3 more
openalex   +1 more source

A phase III randomized controlled trial comparing surgery plus adjuvant chemotherapy with preoperative chemoradiotherapy followed by surgery plus adjuvant chemotherapy for locally recurrent rectal cancer: Japan Clinical Oncology Group study JCOG1801 (RC-SURVIVE study) [PDF]

, 2020
Tomohiro Kadota, Yuichiro Tsukada, Masaaki Ito, Hiroshi Katayama, Junki Mizusawa, Naoki Nakamura, Yoshinori Ito, Hideaki Bando, Masahiko Ando, Hiroaki Onaya, Haruhiko Fukuda, Yukihide Kanemitsu   +11 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Dr. Jane C. Wright (1919-2013): The Architect of Modern Chemotherapy and Clinical Oncology. [PDF]

Cureus
Shah MH.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Unveiling the anticancer potential of SGLT-2 inhibitors: mechanisms and prospects in clinical oncology-a narrative review. [PDF]

Eur J Med Res
Li J, Qiao J, Zhang S, Zhong J, Ke C, Lin Y, Li Y, Jin Y, Yao Y, Zhai A, Bi C.   +10 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Sex and gender differences in cancer research and its application to clinical oncology and therapeutics. [PDF]

Clinics (Sao Paulo)
Lucas-Domínguez R, Rius C, Liu Y, Sixto-Costoya A, Valderrama-Zurián JC.   +4 more
europepmc   +1 more source