Results 241 to 250 of about 1,464,129 (347)

An update from the Pediatric Proton Consortium Registry [PDF]

, 2018
et al,, Perkins, Stephanie M
core   +1 more source

Enabling Just-in-Time Clinical Oncology Analysis With Large Language Models: Feasibility and Validation Study Using Unstructured Synthetic Data.

JMIR Med Inform
May P, Greß J, Seidel C, Sommer S, Schuler MK, Nokodian S, Schröder F, Jung J.   +7 more
europepmc   +1 more source

Comparative Evaluation of LLMs in Clinical Oncology. [PDF]

NEJM AI
Rydzewski NR, Dinakaran D, Zhao SG, Ruppin E, Turkbey B, Citrin DE, Patel KR.   +6 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Personalized medicine: Clinical oncology on molecular view of treatment. [PDF]

World J Clin Oncol
Da Silva RCDS, Simon NA, Dos Santos AA, Olegário GM, Da Silva JF, Sousa NO, Corbacho MAT, de Melo FF.   +7 more
europepmc   +1 more source

American Society of Clinical Oncology Statement: A Conceptual Framework to Assess the Value of Cancer Treatment Options

, 2015
Lowell E. Schnipper, Nancy E. Davidson, Dana S. Wollins, Courtney Tyne, Douglas W. Blayney, Diane Blum, Adam P. Dicker, Patricia A. Ganz, J. Russell Hoverman, Robert M. Langdon, Gary H. Lyman, Neal J. Meropol, Therese M. Mulvey, Lee N. Newcomer, Jeffrey Peppercorn, Blasé N. Polite, Derek Raghavan, Gregory Rossi, Leonard B. Saltz, Deborah Schrag, Thomas J. Smith, Peter Paul Yu, Clifford A. Hudis, Richard L. Schilsky   +23 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Attitudes towards and participation in randomised clinical trials in oncology: A review of the literature

, 2000
Peter Ellis
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Harnessing exosomes as cancer biomarkers in clinical oncology. [PDF]

Cancer Cell Int
Ghosh S, Rajendran RL, Mahajan AA, Chowdhury A, Bera A, Guha S, Chakraborty K, Chowdhury R, Paul A, Jha S, Dey A, Dubey A, Gorai S, Das P, Hong CM, Krishnan A, Gangadaran P, Ahn BC.   +17 more
europepmc   +1 more source