Results 271 to 280 of about 24,824,508 (325)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Clinical Outcome of Extended Endoscopic Endonasal Transclival Approach for Skull Base Lesions. [PDF]

Neurosurg Pract
Vargas-Moreno A, Khairy S, Saymeh M, Lang DK, Yang N, Rabski J, Kilty S, Alkherayf F.   +7 more
europepmc   +1 more source

Spatially defined microenvironmental niches are associated with clinical outcome and tumor ecosystem diversity in head and neck cancer. [PDF]

Med
An J, Hu E, Shen Q, Zhu J, Zhu J, Liu N, Lin Q, Nunez L, Bello S, Ren Y, Kurt S, Harris K, Kawachi N, Rosenblatt G, Ye R, Segall JE, Ostrer H, Hebert T, Fecher R, Liu Q, Aminu M, Ow TJ, Prystowsky MB, Verma A, Deng W, Yin S.   +25 more
europepmc   +1 more source

Cognitive and behavioral clinical outcome assessments in children with developmental and epileptic encephalopathies: Issues and instruments. [PDF]

Epilepsia
Correale C, Specchio N, Downs J, Cross JH, Cappelletti S, Palacio-Navarro A, Geuens S, Valente K, Brunklaus A, Reilly C.   +9 more
europepmc   +1 more source

Impact of Frontline Systemic Treatment Choice on Clinical Outcome in Advanced Leiomyosarcoma: A CanSaRCC Study. [PDF]

Cancer Med
Hein ECK, Gupta A, Soroka HP, Holloway C, Biffart B, Nessim C, Wild T, Lajkosz K, Watson GA, Razak AA, Salawu A.   +10 more
europepmc   +1 more source

Clinical outcome of extremity arterial injuries in the modern era. [PDF]

Turk J Med Sci
Kuşsan A, Coşkun S, Şener A, Içme F, Köksal Coşkun P, Kurtoğlu Çelik G.   +5 more
europepmc   +1 more source