Results 41 to 50 of about 24,824,508 (325)

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

Frontiers in Pharmacology, 2017
Several cancers are highly refractory to conventional chemotherapy. The survival of tumors in several cases is assisted by checkpoint immunomodulation to maintain the imbalance between immune surveillance and cancer cell proliferation.
H. Alsaab, S. Sau, R. Alzhrani, K. Tatiparti, K. Bhise, S. Kashaw, A. Iyer   +6 more
semanticscholar   +1 more source

Comparability of a provisioned device versus bring your own device for completion of patient-reported outcome measures by participants with chronic obstructive pulmonary disease: quantitative study findings

Journal of Patient-Reported Outcomes, 2022
Highlights Historically, provisioned handheld devices [PD] have been provided to participants to enter patient-reported outcome (PRO) data during a clinical trial.
Stacie Hudgens, Louise Newton, Sonya Eremenco, Mabel Crescioni, Tara Symonds, Philip C. G. Griffiths, David S. Reasner, Bill Byrom, Paul O’Donohoe, Susan Vallow, the Patient-Reported Outcome (PRO) Consortium and Electronic Clinical Outcome Assessment (eCOA) Consortium   +10 more
doaj   +1 more source

Implementing an aim-based outcome measure in a psychoanalytic child psychotherapy service: Insights, experiences and evidence [PDF]

, 2014
In this paper, we describe the use of an aim-based outcome measure used in routine outcome monitoring of child and adolescent psychotherapy within a child and adolescent mental health service. We present empirical evidence drawn from a cohort of 34 child
Helen Muller, Emanuel, R, Catty, Jocelyn, Anscombe, Elizabeth, Muller, Helen, Emanuel, Ricky, Cantle, Alison, Anscombe, E, Cantle, A, Catty, J, Ricky Emanuel, Muller, H, Jocelyn Catty, Elizabeth Anscombe, Alison Cantle   +14 more
core   +1 more source

Comparitive Assessment of the Clinical Treatment Outcome and the Predicted Treatment Outcome of Clear Aligner Treatment; In Vivo Study [PDF]

Iranian Journal of Orthodontics, 2019
Objectives: The objective of this clinical study was to assess the predicted treatment outcome and actual treatment outcome and compare the models of both the groups so as to evaluate the efficacy of tooth movement with clear aligner. Methods: The sample
Arisha Izhar, Gurkeerat Singh, Varun Goyal, Rajkumar Singh, Nishant Gupta, Prerna Pahuja   +5 more
doaj   +1 more source

Outcome predictors and clinical presentation of syringomyelia

Asian Journal of Surgery, 2023
Summary: Background: The prognosis of syringomyelia is not yet established. Syringomyelia derived from different etiologies contributes to similar symptoms.
Yun-Cong Zheng, Yin-Tso Liu, Kuo-Chen Wei, Yin-Cheng Huang, Pin-Yuan Chen, Yung-Hsin Hsu, Chih-Lung Lin   +6 more
doaj   +1 more source

Acute cough in Italian children: parents’ beliefs, approach to treatment, and the family impact

Multidisciplinary Respiratory Medicine, 2019
Background Acute cough is the most common symptom among children in primary care, but the impact of cough episodes was never investigated in Italian families.
Roberto W. Dal Negro, Alessandro Zanasi, Paola Turco, Massimiliano Povero   +3 more
doaj   +1 more source

Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials

Alzheimer's & Dementia, 2019
This study estimated the minimal clinically important difference (MCID) for Mini Mental State Examination, Clinical Dementia Rating Scale sum of boxes, and Functional Activities Questionnaire across the Alzheimer's disease (AD) spectrum.
J. Andrews, U. Desai, N. Kirson, M. Zichlin, D. E. Ball, Brandy R. Matthews   +5 more
semanticscholar   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
core  

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Deconstructing therapy outcome measurement with Rasch analysis of a measure of general clinical distress: the Symptom Checklist-90-Revised [PDF]

, 2006
Rasch analysis was used to illustrate the usefulness of item-level analyses for evaluating a common therapy outcome measure of general clinical distress, the Symptom Checklist-90-Revised (SCL-90-R; Derogatis, 1994).
Beltyukova, Svetlana A., Gunderson, Jennifer, Fox, Christine M., Stone, Gregory E., Zhang, Xi, Elliott, Robert   +5 more
core   +4 more sources