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Clinical outcome assessment in clinical trials of chronic pain treatments [PDF]

PAIN Reports, 2021
. Clinical outcome assessments (COAs) measure outcomes that are meaningful to patients in clinical trials and are critical for determining whether a treatment is effective.
Kushang V. Patel, Dagmar Amtmann, Mark P. Jensen, Shannon M. Smith, Christin Veasley, Dennis C. Turk   +5 more
doaj   +4 more sources

Clinical Outcome Assessments Toolbox for Radiopharmaceuticals [PDF]

Frontiers in Oncology, 2019
For nearly 40 years, the U.S. National Cancer Institute (NCI) has funded health-related quality-of-life (HRQOL) and symptom management in oncology clinical trials as a method for including a cancer patient's experience during and after treatment. The NCI'
Charles A. Kunos, Jacek Capala, Adam P. Dicker, Benjamin Movsas, Susan Percy Ivy, Lori M. Minasian   +5 more
doaj   +4 more sources

Clinical outcome assessment trends in clinical trials—Contrasting oncology and non‐oncology trials [PDF]

Cancer Medicine, 2023
Background Clinical outcome assessments (COAs) are key to patient‐centered evaluation of novel interventions and supportive care. COAs are particularly informative in oncology where a focus on how patients feel and function is paramount, but their ...
Yeonju Kim, Mark R. Gilbert, Terri S. Armstrong, Orieta Celiku   +3 more
doaj   +2 more sources

Clinical Outcomes Assessment in Clinical Trials to Assess Treatment of Femoroacetabular Impingement: Use of Patient-reported Outcome Measures [PDF]

Journal of the American Academy of Orthopaedic Surgeons, 2013
Patient-reported outcome measures are an important component of outcomes assessment in clinical trials to assess the treatment of femoroacetabular impingement (FAI). This review of disease-specific measures and instruments used to assess the generic quality of life and physical activity levels of patients with FAI found no conclusive evidence to ...
Harris-Hayes, Marcie, McDonough, Christine M, Leunig, Michael, Lee, Cara Beth, Callaghan, John J, Roos, Ewa M.   +5 more
openaire   +5 more sources

A Guide to the Language of Clinical Outcome Assessment [PDF]

Global Spine Journal, 2020
Daniel C Norvell, Joseph R. Dettori, Jens R. Chapman   +2 more
openaire   +3 more sources

Clinical Outcome Assessments: Conceptual Foundation—Report of the ISPOR Clinical Outcomes Assessment – Emerging Good Practices for Outcomes Research Task Force [PDF]

Value in Health, 2015
An outcome assessment, the patient assessment used in an endpoint, is the measuring instrument that provides a rating or score (categorical or continuous) that is intended to represent some aspect of the patient's health status. Outcome assessments are used to define efficacy endpoints when developing a therapy for a disease or condition. Most efficacy
Marc K. Walton, Patrick Marquis, Donald L. Patrick, Maria Isaac, Sprios Vamvakas, Stefan J. Cano, Elizabeth Molsen, Laurie B. Burke, John H. Powers, Jeremy Hobart   +9 more
openaire   +4 more sources

Fundamentals of Clinical Outcomes Assessment for Spinal Disorders: Clinical Outcome Instruments and Applications

Global Spine Journal, 2015
Study Design A broad narrative review. Objectives Outcome assessment in spinal disorders is imperative to help monitor the safety and efficacy of the treatment in an effort to change the clinical practice and improve patient outcomes. The following article, part two of a two-part series, discusses the various outcome tools and instruments utilized to ...
Julia Quidde, Patrick Vavken, Patrick Vavken, Anne Kathleen B. Ganal-Antonio, Jens R. Chapman, Dino Samartzis, Francis H. Shen   +6 more
openaire   +6 more sources

Non-Small Cell Lung Cancer Symptom Assessment Questionnaire (NSCLC-SAQ): Measurement Properties and Estimated Clinically Meaningful Thresholds From a Phase 3 Study

JTO Clinical and Research Reports, 2022
Introduction: The NSCLC Symptom Assessment Questionnaire (NSCLC-SAQ) was developed to assess NSCLC symptom severity in accordance with Food and Drug Administration evidentiary expectations leading to Food and Drug Administration qualification in 2018 ...
Paul Williams, MPH, Thomas Burke, PharmD, PhD, Josephine M. Norquist, MS, Christina Daskalopoulou, PhD, Rebecca M. Speck, PhD, MPH, Ayman Samkari, MD, Sonya Eremenco, MA, Stephen Joel Coons, PhD   +7 more
doaj   +1 more source

Tumor-infiltrating lymphocytes provides recent survival information for early-stage HER2-low-positive breast cancer: a large cohort retrospective study

Frontiers in Oncology, 2023
PurposeIt has been reported that breast cancer (BC) with low expression of human epidermal growth factor receptor 2 (HER2) might be a distinct subtype of BC. However, the prognostic effect of low HER2 expression on BC patients remains controversial.
Teng Sun, Teng Sun, Tong Wang, Xiangjun Li, Xiangjun Li, Haibo Wang, Haibo Wang, Yan Mao, Yan Mao   +8 more
doaj   +1 more source

Comparability of a provisioned device versus bring your own device for completion of patient-reported outcome measures by participants with chronic obstructive pulmonary disease: qualitative interview findings

Journal of Patient-Reported Outcomes, 2022
Background There is interest in participants using their own smartphones or tablets (“bring your own device”; BYOD) to complete patient-reported outcome (PRO) measures in clinical studies.
Louise Newton, Oliver Knight-West, Sonya Eremenco, Stacie Hudgens, Mabel Crescioni, Tara Symonds, David S. Reasner, Bill Byrom, Paul O’Donohoe, Susan Vallow, the Patient-Reported Outcome (PRO) Consortium, Electronic Clinical Outcome Assessment (eCOA) Consortium   +11 more
doaj   +1 more source