Results 11 to 20 of about 1,249,695 (291)

Long-term progression of clinician-reported and gait performance outcomes in hereditary spastic paraplegias

Frontiers in Neuroscience, 2023
IntroductionHereditary spastic paraplegias (HSPs) are a heterogeneous group of neurodegenerative diseases in which little is known about the most appropriate clinical outcome assessments (COAs) to capture disease progression.
Diana Maria Cubillos Arcila, Diana Maria Cubillos Arcila, Gustavo Dariva Machado, Valéria Feijó Martins, Vanessa Bielefeldt Leotti, Vanessa Bielefeldt Leotti, Rebecca Schüle, Leonardo Alexandre Peyré-Tartaruga, Leonardo Alexandre Peyré-Tartaruga, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute   +13 more
doaj   +1 more source

Comparability of a provisioned device versus bring your own device for completion of patient-reported outcome measures by participants with chronic obstructive pulmonary disease: quantitative study findings

Journal of Patient-Reported Outcomes, 2022
Highlights Historically, provisioned handheld devices [PD] have been provided to participants to enter patient-reported outcome (PRO) data during a clinical trial.
Stacie Hudgens, Louise Newton, Sonya Eremenco, Mabel Crescioni, Tara Symonds, Philip C. G. Griffiths, David S. Reasner, Bill Byrom, Paul O’Donohoe, Susan Vallow, the Patient-Reported Outcome (PRO) Consortium and Electronic Clinical Outcome Assessment (eCOA) Consortium   +10 more
doaj   +1 more source

How Much Evidence Is Enough? Research Sponsor Experiences Seeking Regulatory Acceptance of Digital Health Technology-Derived Endpoints

Digital Biomarkers, 2023
Introduction: Digital health technologies (DHTs) provide opportunities for real-time data collection and assessment of patient function. However, use of DHT-derived endpoints in clinical trials to support medical product labelling claims is limited ...
Brian Perry, Lindsay Kehoe, Teresa Swezey, Quentin Le Masne, Jörg Goldhahn, Alicia Staley, Amy Corneli   +6 more
doaj   +1 more source

Weighted Trajectory Analysis and Application to Clinical Outcome Assessment

BioMedInformatics, 2023
The Kaplan–Meier (KM) estimator is widely used in medical research to estimate the survival function from lifetime data. KM estimation is a powerful tool to evaluate clinical trials due to simple computational requirements, its use of a logrank ...
Utkarsh Chauhan, Kaiqiong Zhao, John Walker, John R. Mackey   +3 more
doaj   +1 more source

Novel Approaches to Air Pollution Exposure and Clinical Outcomes Assessment in Environmental Health Studies

Atmosphere, 2020
An accurate assessment of pollutants’ exposure and precise evaluation of the clinical outcomes pose two major challenges to the contemporary environmental health research.
Shaked Yarza, Lior Hassan, Alexandra Shtein, Dan Lesser, Lena Novack, Itzhak Katra, Itai Kloog, Victor Novack   +7 more
doaj   +1 more source

Assessing Clinical Outcomes [PDF]

Journal of Pain and Symptom Management, 1998
The problem of unresolved pain in hospitalized patients is costly both in monetary terms and in patient comfort. Concern about patients' satisfaction and well-being led to a study to determine the characteristics of the pain experience as reported by the hospitalized patients.
Gwen Sherwood, Jeanette A. McNeill, Cathy J. Thompson, Patricia L. Starck   +3 more
openaire   +2 more sources

The Transthyretin Amyloidosis – Quality of Life (ATTR-QOL) Questionnaire: Development of a Conceptual Model and Disease-Specific Patient-Reported Outcome Measure

Patient Related Outcome Measures, 2023
Meaghan O’Connor,1 Kristen Hsu,2 Lynne Broderick,1 Kristen L McCausland,1 Kaitlin LaGasse,1 Sabrina Rebello,2 Michelle Carty,1 Isabelle Lousada2 1QualityMetric Incorporated LLC, Johnston, RI, USA; 2Amyloidosis Research Consortium, Newton, MA ...
O'Connor M, Hsu K, Broderick L, McCausland KL, LaGasse K, Rebello S, Carty M, Lousada I   +7 more
doaj  

A post pandemic roadmap toward remote assessment for neuromuscular disorders: limitations and opportunities

Orphanet Journal of Rare Diseases, 2022
Recent advances in technology and expanding therapeutic opportunities in neuromuscular disorders has resulted in greater interest in and development of remote assessments.
Jacqueline Montes, Katy J. Eichinger, Amy Pasternak, Cara Yochai, Kristin J. Krosschell   +4 more
doaj   +1 more source

Clinical validation of a body-fixed 3D accelerometer and algorithm for activity monitoring in orthopaedic patients

Journal of Orthopaedic Translation, 2017
Background/Objective: Activity is increasingly being recognized as a highly relevant parameter in all areas of healthcare for diagnosis, treatment, or outcome assessment, especially in orthopaedics where the movement apparatus is directly affected ...
Matthijs Lipperts, Simon van Laarhoven, Rachel Senden, Ide Heyligers, Bernd Grimm   +4 more
doaj   +1 more source

Developing Angelman syndrome-specific clinician-reported and caregiver-reported measures to support holistic, patient-centered drug development

Orphanet Journal of Rare Diseases, 2023
Background Angelman syndrome (AS) is a rare, heterogenous neurogenetic condition, which significantly impacts the lives of people with AS and their families. Valid and reliable measures reporting key symptoms and functional impairments of AS are required
Siobhan Connor-Ahmad, Jorrit Tjeertes, Michael Chladek, Louise Newton, Tara Symonds, Susanne Clinch, Brenda Vincenzi, Fiona McDougall   +7 more
doaj   +1 more source