Results 31 to 40 of about 1,249,695 (291)

An Assessment of Hand Erosive Osteoarthritis: Correlation of Radiographic Severity with Clinical, Functional and Laboratory Findings

Rheumatology and Therapy, 2019
Introduction The present study aimed (a) to evaluate the clinical and radiographic characteristics of hand erosive osteoarthritis (EOA) in a group of consecutive patients, (b) to correlate the severity of radiographic involvement with clinical and ...
Fabio Massimo Perrotta, Silvia Scriffignano, Antonia De Socio, Ennio Lubrano   +3 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Establishing meaningful change thresholds for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire CLL‐specific module domain scores: An analysis based on the TRANSCEND CLL 004 study in patients with relapsed or refractory chronic lymphocytic leukaemia or small lymphocytic lymphoma

eJHaem
Introduction The study aimed to establish meaningful thresholds at patient and group levels for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire CLL‐specific module (EORTC QLQ‐CLL17) domain scores in adults ...
Laurie Eliason, Fatoumata Fofana, Lin Wang, Peter A. Riedell, Shien Guo   +4 more
doaj   +1 more source

Initial Patient Assessment Workshop

MedEdPORTAL, 2010
Introduction In a small-group workshop setting, medical students work with a clinical facilitator on eight basic clinical scenarios. The intention is to guide learners through how they would approach initial assessment of a patient and to help them begin
John Mahoney
doaj   +1 more source

Outcomes in intervention research on snakebite envenomation: a systematic review [version 1; peer review: 2 approved]

F1000Research, 2022
Introduction: A core outcome set (COS) is a minimal list of consensus outcomes that should be used in all intervention research in a specific domain. COS enhance the ability to undertake meaningful comparisons and to understand the benefits or harms of ...
Jyoti Tyagi, Paula R Williamson, Deepti Beri, Mike Clarke, Sanjib Kumar Sharma, Soumyadeep Bhaumik, Jagnoor Jagnoor   +6 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Evaluation of the efficacy and safety of sarilumab combination therapy in patients with rheumatoid arthritis with inadequate response to conventional disease-modifying antirheumatic drugs or tumour necrosis factor α inhibitors: systematic literature review and network meta-analyses

RMD Open, 2019
Objective To compare efficacy and safety of subcutaneous sarilumab 200 mg and 150 mg every 2 weeks plus conventional synthetic disease-modifying antirheumatic drugs (+csDMARDs) versus other targeted DMARDs+csDMARDs and placebo+csDMARDs, in inadequate ...
Ernest Choy, Nick Freemantle, Clare Proudfoot, Chieh-I Chen, Laurence Pollissard, Andreas Kuznik, Hubert Van Hoogstraten, Erin Mangan, Paulo Carita, Thi-Minh-Thao Huynh   +9 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Impact of preeclampsia on maternal and neonatal health: A retrospective cohort study

Russian Open Medical Journal
Objective — Understanding the relationship between maternal characteristics of patients with preeclampsia (PE) and disease progression, as well as the impact on neonatal and parturient outcomes, is critical to the development of effective interventions ...
Sakine Rahimli Ocakoglu, Zeliha Atak, Burak Akselim, Seniha Gunduz Corabay, Merve Erten Esen   +4 more
doaj   +1 more source

Deconstructing the Minimum Clinically Important Difference (MCID)

Orthopedic Research and Reviews, 2022
Janine Molino,1,2 Joseph Harrington,2 Jennifer Racine-Avila,2 Roy Aaron2 1Lifespan Biostatistics Core, Rhode Island Hospital, Providence, RI, USA; 2Department of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI ...
Molino J, Harrington J, Racine-Avila J, Aaron R   +3 more
doaj