Results 81 to 90 of about 2,569,145 (337)

The effects of donepezil in Alzheimer's disease - Results from a multinational trial [PDF]

, 1999
Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD).
Burns, A., Friedhoff, L. T., Gauthier, S., Hecker, J., Möller, Hans-Jürgen, Petit, H., Rogers, S. L., Rossor, M.   +7 more
core   +1 more source

Assessing Participant-Centered Outcomes to Improve Clinical Research [PDF]

New England Journal of Medicine, 2013
The value of patient-centered outcome measures for improving care is now well established. In contrast, research participants' perspectives on aspects of their research experiences, such as whether the informed-consent process prepared them for participation, are rarely examined.
Rhonda G, Kost, Laura M, Lee, Jennifer, Yessis, Robert A, Wesley, David K, Henderson, Barry S, Coller   +5 more
openaire   +2 more sources

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

A protocol for a randomised controlled trial of prefabricated versus customised foot orthoses for people with rheumatoid arthritis: the FOCOS RA trial [Foot Orthoses – Customised v Off-the-Shelf in Rheumatoid Arthritis] [PDF]

, 2018
Background Foot pain is common in rheumatoid arthritis and appears to persist despite modern day medical management. Several clinical practice guidelines currently recommend the use of foot orthoses for the treatment of foot pain in people with ...
Gallagher, Kellie S., Godwin, Jon, Hendry, Gordon J., Steultjens, Martijn, Woodburn, James   +4 more
core   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Assessing clinical meaningfulness in clinical trials for Alzheimer's disease: A U.S. regulatory perspective

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
In the context of recent approvals of amyloid‐directed monoclonal antibodies for the treatment of Alzheimer's disease (AD) by the United States (U.S.) Food and Drug administration (FDA), there has been much public discussion regarding the meaningfulness ...
Teresa Buracchio, Michelle Campbell, Kevin Krudys   +2 more
doaj   +1 more source

Improving estimation of the prognosis of childhood psychopathology; combination of DSM-III-R/DISC diagnoses and CBCL scores [IF: 2.7] [PDF]

, 2004
Objective: To compare the predictive validity of the clinical-diagnostic and the empirical-quantitative approach to assessment of childhood psychopathology, and to investigate the usefulness of combining both approaches. Method: A referred sample (N=96),
Achenbach T.M., Achenbach T.M., Achenbach T.M., Achenbach T.M., American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Biederman J., Edelbrock G., Gould M.S., Heijmens Visser J., Jensen P.S., Kashani J.J., Kasius M., Kasius M.C., Last C.G., Last C.G., Lowry-Webster H.M., NIMH (National Institute of Mental Health), Os J., Piacentini J., Rothman K.J., Schwab-Stone M., Shaffer D., Steingard R., Verhulst F.C., Westerlaak J.H.   +26 more
core   +3 more sources

Fundamentals of Clinical Outcomes Assessment for Spinal Disorders: Clinical Outcome Instruments and Applications

Global Spine Journal, 2015
Study Design A broad narrative review. Objectives Outcome assessment in spinal disorders is imperative to help monitor the safety and efficacy of the treatment in an effort to change the clinical practice and improve patient outcomes. The following article, part two of a two-part series, discusses the various outcome tools and instruments utilized to ...
Chapman, J, Vavken, P, Ganal-Antonio, AKB, Quidde, J, Shen, FH, Samartzis, D   +5 more
openaire   +4 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients with prostate-specific antigen 2-10ng/ml at initial biopsy [PDF]

, 2018
BACKGROUND: Discriminating indolent from clinically significant prostate cancer (PCa) in the initial biopsy setting remains an important issue. Prospectively evaluated diagnostic assays are necessary to ensure efficacy and clinical adoption.
Andriole, Gerry, Brown, Gordon, Carroll, Peter, Carter, Ballentine, Donovan, Michael J, Margolis, Eric, McKiernan, James, Noerholm, Mikkel, Partin, Alan, Shore, Neal, Skog, Johan, Thompson, Ian, Torkler, Phillipp   +12 more
core   +1 more source