Results 81 to 90 of about 4,732,881 (277)

Assessing clinical meaningfulness in clinical trials for Alzheimer's disease: A U.S. regulatory perspective

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions
In the context of recent approvals of amyloid‐directed monoclonal antibodies for the treatment of Alzheimer's disease (AD) by the United States (U.S.) Food and Drug administration (FDA), there has been much public discussion regarding the meaningfulness ...
Teresa Buracchio   +2 more
doaj   +1 more source

Flexible approaches to eCOA administration in clinical trials: The site perspective

open access: yesContemporary Clinical Trials Communications
The Critical Path Institute convened the Support Flexible Approaches to PRO Data Collection project as part of the eCOA: Getting Better Together Initiative which was instigated to identify and address common challenges and drive positive change with eCOA
Estelle Haenel   +4 more
doaj   +1 more source

Qualitative outcome assessment and research on chronic disease management in general practice : highlights from a keynote lecture, EGPRN May 2011, Nice [PDF]

open access: yes, 2012
At its 2011 conference in Nice, France, the European General Practice Research Network (EGPRN), considered the issue of Relevant Outcome Measures in General Practice Research into Chronic Diseases.
Griffiths, Frances
core   +1 more source

Assessment of Clinical Outcomes in Acute Stroke Trials [PDF]

open access: yesStroke, 1998
Background and Purpose —Adequate outcome assessment is crucial to randomized trials. We wished to assess the types of outcomes used in acute stroke trials and the appropriateness of these outcomes and their analyses. Methods —Acute stroke trials from the Cochrane Stroke Group’s ...
Carl Counsell, Lucy Roberts
openaire   +3 more sources

Age as a determinant of nutritional status: A cross sectional study [PDF]

open access: yes, 2005
Background Undenutrition is known to be prevalent and largely unrecognised in older patients; however, aberrations in indicators of nutritional status may simply reflect effects of age and/or functional disability.
Forster, S., Gariballa, S.
core   +4 more sources

Towards a novel clinical outcome assessment for systemic lupus erythematosus: first outcomes of an international taskforce

open access: yesNature Reviews Rheumatology, 2023
K. Connelly   +27 more
semanticscholar   +1 more source

Immunohistochemical determination of oestrogen receptor: comparison of different methods of assessment of staining and correlation with clinical outcome of breast cancer patients.

open access: yesBritish Journal of Cancer, 1996
Immunohistochemical staining for oestrogen receptor (ER) has been carried out using antibody ER ID5 on 170 women who received first-line tamoxifen treatment for evaluable metastatic breast cancer.
D. Barnes   +4 more
semanticscholar   +1 more source

Implementing musculoskeletal outcome assessments in clinical practice [PDF]

open access: yesHaemophilia, 2012
Summary.  Standardized outcome measures allow us to be more objective when measuring the impact of therapy on persons with haemophilia. Many excellent measures have been developed for haemophilia – especially in the health domains of structure and function, and activities; excellent health status/health‐related quality‐of‐life tools have also been ...
openaire   +3 more sources

A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients with prostate-specific antigen 2-10ng/ml at initial biopsy [PDF]

open access: yes, 2018
BACKGROUND: Discriminating indolent from clinically significant prostate cancer (PCa) in the initial biopsy setting remains an important issue. Prospectively evaluated diagnostic assays are necessary to ensure efficacy and clinical adoption.
Andriole, Gerry   +12 more
core   +1 more source

Quality of life in patients with intermittent claudication [PDF]

open access: yes, 2017
© 2017, The Author(s). Background: Intermittent claudication (IC) is a common condition that causes pain in the lower limbs when walking and has been shown to severely impact the quality of life (QoL) of patients.
Broadbent, E.   +4 more
core   +1 more source

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