Results 121 to 130 of about 1,686,489 (300)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Plasma concentration of thrombopoietin in dogs with immune thrombocytopenia

Journal of Veterinary Internal Medicine
Background Immune thrombocytopenia (ITP) is a common cause of severe thrombocytopenia in dogs. The pathogenesis of nonassociative, primary ITP (pITP) appears complex, with ill‐defined thrombopoietic response.
Marjory B. Brooks, James C. Brooks, Jim Catalfamo, Yao Zhu, Robert Goggs, Susanna Babasyan, Bettina Wagner, Dana N. LeVine   +7 more
doaj   +1 more source

Compulsive exercise as a mediator between clinical perfectionism and eating pathology

, 2016
The aim of this study was to examine whether compulsive exercise mediates the relationship between clinical perfectionism and eating pathology, based on the cognitive behavioral model of compulsive exercise.
Egan, Sarah J., Watson, Hunna J, Valentine, Emily, Hagger, Martin S, Egan, Sarah, Hagger, Martin, Watson, H., Egan, Sarah J, Watson, Hunna J., Shu, Chloe, Shu, C., Bodill, Kate   +11 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Urine Neutrophil Gelatinase‐Associated Lipocalin in Non‐Associative Immune Mediated Hemolytic Anemia: A Prospective Controlled Study in 22 Dogs

Journal of Veterinary Internal Medicine
Background Urine neutrophil gelatinase‐associated lipocalin (uNGAL) is a biomarker for the early diagnosis of AKI. Objectives To evaluate uNGAL in dogs with non‐associative immune mediated hemolytic anemia (IMHA) and to evaluate whether uNGAL correlates ...
Vasiliki Lantzaki, Emily A. Fulton, Mark McLaughlin, Euan D. Bennet, Elizabeth A. Conway, Alison E. Ridyard   +5 more
doaj   +1 more source

Increased Erythrocyte Sedimentation Rate in Dogs: Frequency in Routine Clinical Practice and Association with Hematological Changes

Animals
(1) Background: the erythrocyte sedimentation rate (ESR) has been reported to increase in some infectious or inflammatory diseases in dogs, but no information on the frequency of increases in a routine clinical setting exists.
Saverio Paltrinieri, Roberta Ferrari, Donatella Scavone, Carolina Pieroni, Daniela Diamanti, Filippo Tagliasacchi   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinicopathologic features and surgical treatment prognosis of esophageal carcinosarcoma

Frontiers in Oncology
BackgroundCarcinosarcoma is a rare esophageal tumor, accounting for approximately 0.27-2.8% of malignant esophageal tumors. This study aims to investigate the clinical pathological characteristics, surgical treatment outcomes, and analysis of prognostic ...
Jiangfeng Shen, Kaijin Lu, Fuxing Liu, Xia Chen, Quan Chen, Bingbing Wu, Hailan Wang, Pengfei Ge, Guang Han, Fei Wang, Peng Zhang, Pei Yin, Weiguang Jia, Yiming Zheng, Pengcheng Wang, Fei Sun   +15 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source