Results 161 to 170 of about 1,686,489 (300)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Artificial Intelligence in Veterinary Clinical Pathology-An Introduction and Review. [PDF]

Vet Clin Pathol
Neal SV, Rudmann DG, Corps KN.
europepmc   +1 more source

fastMRI+, Clinical pathology annotations for knee and brain fully sampled magnetic resonance imaging data. [PDF]

Sci Data, 2022
Zhao R, Yaman B, Zhang Y, Stewart R, Dixon A, Knoll F, Huang Z, Lui YW, Hansen MS, Lungren MP.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effects of intravenous infusion, vest wearing and repeated intravenous blood collection on clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis). [PDF]

Exp Anim, 2023
Zhao Q, Li C, Chen Y, Liu Y, Wang S, Wang X.   +5 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

A new murine gram-negative sepsis model with standard care satisfies Sepsis-3 and reproduces clinical pathology. [PDF]

Intensive Care Med Exp
Bastow CR, Mei C, Wen SW, Wilson JL, Nguyen H, Suthya AR, Bourne JH, Lankadeva YR, Wong CHY.   +8 more
europepmc   +1 more source

Age- and sex-related changes in body weights and clinical pathology analytes in cynomolgus monkeys (Macaca Fascicularis) of Mauritius origin. [PDF]

Vet Clin Pathol, 2022
Li X, Li D, Biddle KE, Portugal SS, Li MR, Santos R, Burkhardt JE, Khan NK.   +7 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Evaluation of imputation strategies for multi-centre studies: Application to a large clinical pathology dataset. [PDF]

PLoS One
Grigoroff L, Masuda R, Lindon J, Kadyrov J, Nicholson JK, Holmes E, Wist J.   +6 more
europepmc   +1 more source