Results 191 to 200 of about 1,695,081 (360)

miR-22-3p Suppresses Endothelial Progenitor Cell Proliferation and Migration via Inhibiting Onecut 1 (OC1)/Vascular Endothelial Growth Factor A (VEGFA) Signaling Pathway and Its Clinical Significance in Venous Thrombosis

, 2020
Huoqi Liang, Yibiao Chen, Hefei Li, Xiao‐Qiang Yu, Chunqiu Xia, Zhibing Ming, Chongjun Zhong   +6 more
openalex   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Acute Suspected Stroke Clinical Pathway Use in Tasmanian Emergency Departments: A Retrospective Study. [PDF]

Emerg Med Australas
Mudzingwa IT, Prior SJ, Griffin P, Tavender E, Tran V.   +4 more
europepmc   +1 more source

A Feasibility Study of One Clinical Pathway for Both Distal and Total Gastrectomy

, 2013
Isao Nozaki, Naoto Gotohda, Tsuneaki Fujiya, Norimasa Fukushima, Junya Fujita, Seiji Ito, Hiroo OSHITA, Susumu Kawamura, Fumihiko Wakao, Akira Kurita   +9 more
openalex   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pharmacological studies of a novel inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway

, 2010
The apoptotic mode of cell death (programmed cell death) is an active and defined process that plays an important role in the development of multicellular organisms and in the regulation and maintenance of cell populations in tissues under physiologic ...
Morad, Samy
core  

A Care Transitions Electronic Clinical Pathway for Patients With Chronic Conditions: Qualitative Secondary Analysis. [PDF]

J Particip Med
Roman Jones J, Wu H, Tejeda CJ, McCoy AB, Samal L, Dykes PC.   +5 more
europepmc   +1 more source

Table 5_Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.xlsx

Jiayin Gong (18594817), Mingxing Lin (7479626), Lizhen Chen (358286), Wenting Xiong (18695878), Yuying Zhang (634603), Changyun Liu (7330526), Shenggen Chen (18695881), Wanhui Lin (11423491), Chaofeng Zhu (11423494), Huapin Huang (11423506)   +9 more
openalex   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Clinical Pathway [PDF]

, 2020
openaire   +1 more source