Results 11 to 20 of about 2,614,061 (283)

MTOR cross-talk in cancer and potential for combination therapy [PDF]

, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C., Bria, E., Ciuffreda, L., Cognetti, F., Conciatori, F., Falcone, I., Milella, M, Pilotto, S.   +7 more
core   +6 more sources

Clinical Pathways to Ethically Substantive Autonomy [PDF]

, 2013
There is no shortage of support for the idea that ethics should be incorporated into the academic and professional curriculum. There is a difference, however, between, on the one hand, teaching professionals about ethics, and, on the other, demanding ...
Drake, Philip, Toddington, Stuart
core   +3 more sources

Building Data-Driven Pathways From Routinely Collected Hospital Data:A Case Study on Prostate Cancer [PDF]

, 2015
Background: Routinely collected data in hospitals is complex, typically heterogeneous, and scattered across multiple Hospital Information Systems (HIS).
Adriansyah, A, Cios, KJ, Holmström, Benny, Lang, M, Luc, Kd, Mans, R, Mans, R, Pearson, SD, Safran, C   +8 more
core   +2 more sources

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaminski, Rafal M., Kaufer, Daniela, Koh, Sookyong, Lã¶scher, Wolfgang, Louboutin, Jean-pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria   +17 more
core   +17 more sources

Identification of molecular markers of delayed graft function based on the regulation of biological ageing [PDF]

, 2016
Introduction: Delayed graft function is a prevalent clinical problem in renal transplantation for which there is no objective system to predict occurrence in advance.
Aitken, Emma, Clancy, Marc, Gingell-Littlejohn, Marc, Kerschbaum, Julia, Kingsmore, David B., Koppelstaetter, Christian, Königsrainer, Alfred, Leierer, Johannes, Little, Ann-Margaret, Maglione, Manuel, McConnachie, Alex, McGuinness, Dagmara, Mohammed, Suhaib, Nadalin, Silvio, Schneeberger, Stefan, Shapter, Olivier, Shiels, Paul G., Stevenson, Karen S., Wagner, Sylvia, Whalen, Henry   +19 more
core   +8 more sources

An evaluation of DNA-damage response and cell-cycle pathways for breast cancer classification [PDF]

, 2014
Accurate subtyping or classification of breast cancer is important for ensuring proper treatment of patients and also for understanding the molecular mechanisms driving this disease.
Fard, Atefeh Taherian, Ragan, Mark A., Srihari, Sriganesh   +2 more
core   +5 more sources

Updated management of malignant biliary tract tumors: an illustrative review [PDF]

, 2016
The management of malignant biliary tumors (MBTs) is complex and requires a multidisciplinary approach. Guidelines and methods of staging for biliary tumors have recently been released by main international societies, altering the clinical and radiologic
Cannavale, Alessandro, Catalano, Carlo, Fanelli, Fabrizio, Fiocca, Fausto, Gazzetti, Marianna, Maher, Ben, Santoni, Mariangela   +6 more
core   +1 more source

Cancer Clinical Trials Optimization and Pharmacogenomics [PDF]

, 2012
A critical overview of recent clinical trials in cancer is presented focused on signaling pathways blockers or inhibitors with a view to developing successful clinical trials employing personalized cancer therapies.
I. C. Baianu
core   +2 more sources

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Bakin RE, Buchanan G, Chang C, Davies MA, Malik SN, Marcelli M, Taplin ME, Thakkar H   +7 more
core   +1 more source

Exploring glycosuria as a mechanism for weight and fat mass reduction. A pilot study with remogliflozin etabonate and sergliflozin etabonate in healthy obese subjects

Journal of Clinical & Translational Endocrinology, 2014
Inhibitors of sodium-dependent glucose co-transporter 2 (SGLT2) increase glucose excretion in the urine and improve blood glucose in Type 2 diabetes mellitus. Glycosuria provides an energy and osmotic drain that could alter body composition. We therefore
Antonella Napolitano, Sam Miller, Peter R. Murgatroyd, Elizabeth Hussey, Robert L. Dobbins, Edward T. Bullmore, Derek J.R. Nunez   +6 more
doaj   +1 more source