Results 21 to 30 of about 951,333 (183)

Pathways to inflated responsibility beliefs in adolescent obsessive-compulsive disorder: a preliminary investigation [PDF]

, 2010
Background: An inflated sense of responsibility is characteristic of obsessive-compulsive disorder (OCD). No previous studies have investigated its origins. Five potential pathways to inflated responsibility beliefs have been proposed; these are tested
Lawrence, P. J. P., Williams, Tim I.
core   +1 more source

Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]

, 2011
Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny, Liau, Linda M, Liu, Yue, Tso, Cho-Lea, Tso, Jonathan, Yamada, Kazunari, Ye, Fei   +6 more
core   +1 more source

Strategic Use of Clinical Pathways [PDF]

Journal of Oncology Practice, 2011
Clinical pathways are detailed, evidence-based processes for delivering cancer care for specific patient presentations. Some oncologists have embraced clinical pathways, while others resist.
Dean H. Gesme, Marian Wiseman
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]

, 2012
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
A Bosutti, A Jellema, A Laugeray, A Peters, A Rossi-George, A Schaffner, AA Wadee, AH Swiergiel, AJ Grossberg, AL Hassett, AL Lacerda, AM Myint, AN van den Pol, AS El-Radhi, AS Wrynn, AY Lai, B Leonard, B Owe-Larsson, BE Leonard, BE Leonard, BG Charlton, BL Hart, Brian Leonard, C Celik, C Nathan, C Song, C Song, C Song, C Song, C Song, CA Stockmeier, Cai Song, CL Raison, D Brustolim, D Wang, DK Kinney, EA Stone, ES Wohleb, F Frenois, F Kapczinski, F Moroni, G Anderson, G Werner-Felmayer, George Anderson, GM MacQueen, GR Steinberg, H Anisman, H Anisman, H Nakanishi, HC Liu, HP Kopp, I Kirsch, IK Lampe, IR Bell, J Hannestad, J Steiner, JC O'Connor, JE Bower, JE Holmes, JL Rausch, JM Twenge, KJ Jung, KJ Tracey, KS Kendler, L MacDonald, L Qin, L Toker, LE Goehler, LE Goehler, Lisa Goehler, LJ Williams, LM Harden, LV Kessing, LV Kessing, M Adib-Conquy, M Berk, M Berk, M Berk, M Berk, M Catena-Dell'Osso, M Kauer-Sant'Anna, M Koenigs, M Kubera, M Kubera, M Lyte, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, MB Hennessy, MB Howren, MC McKinnon, MC Wichers, MC Wichers, MC Wichers, MD Burton, ME Sublette, Michael Berk, Michael Maes, MJ Hoes, MJ Kluger, MJ Kluger, MJ Sharman, MP Szuba, MT Berlim, N Castanon, N Castex, NA Harrison, O Caliyurt, O Takikawa, P Gorwood, P Taepavarapruk, P Videbech, Piotr Gałecki, R Dantzer, R Medzhitov, R Roubenoff, R Yirmiya, RC Bone, RH Straub, RJ Boland, RK Jewkes, RK Kumar, RM Post, RPA Gaykema, RPA Gaykema, RPA Gaykema, RW Johnson, S Bonaccorso, S Bonaccorso, S Cunningham-Rundles, S Lacosta, S Rantala, S-M Park, SC Strijdom, SD Burdette, SE Møller, SF Maier, SM Antelman, SM Jancsár, SM O'Brien, SM Sylvén, T Hochstrasser, T Liukkonen, T Sato, T Tuma, TA Lennie, TC Olde Hartman, TM Piser, V Gabbay, WC Drevets, WS Yang, Y Dowlati, Y Huang, Y Jiang, Y Kawasaki, Y Liu, Z Pavlovićc, Z Xia   +189 more
core   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Bakin RE, Buchanan G, Chang C, Davies MA, Malik SN, Marcelli M, Taplin ME, Thakkar H   +7 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Targeted antiangiogenic agents in combination with cytotoxic chemotherapy in preclinical and clinical studies in sarcoma. [PDF]

, 2016
Sarcomas are a heterogeneous group of mesenchymal malignancies. In recent years, studies have demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the growth of sarcomas.
DuBois, Steven G, Matthay, Katherine K, Vo, Kieuhoa T   +2 more
core   +1 more source