Results 241 to 250 of about 10,256,810 (359)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The potential for clinical pharmacists to support older people with dementia in the community: A qualitative interview study. [PDF]

Br J Clin Pharmacol
Burnand A, Woodward A, Kantilal K, Bhanu C, Jani Y, Manthorpe J, Orlu M, Rait G, Sajid M, Samsi K, Vickerstaff V, Ward J, Wilcock J, Davies N.   +13 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Integrating clinical pharmacists in care management for secondary stroke prevention clinical trials: a scoping review. [PDF]

Front Neurol
Thurston J, Li H, Kronish IM, Naqvi IA.
europepmc   +1 more source

Community Health Workers Supporting Clinical Pharmacists in Diabetes Management: A Randomized Controlled Trial

Pharmacotherapy, 2018
L. Sharp, Jessica J. Tilton, D. Touchette, Yinglin Xia, D. Mihailescu, M. Berbaum, B. Gerber   +6 more
semanticscholar   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Understanding structured medication reviews delivered by clinical pharmacists in primary care in England: a national cross-sectional survey. [PDF]

BMJ Open
Agwunobi AJ, Seeley AE, Tucker KL, Bateman PA, Clark CE, Clegg A, Ford G, Gadhia S, Hobbs FDR, Khunti K, Lip GYH, de Lusignan S, Mant J, McCahon D, Payne RA, Perera R, Seidu S, Sheppard JP, Williams M, Wright-Drakesmith C, McManus RJ, Barnes RK.   +21 more
europepmc   +1 more source

Clinical pharmacists in general practice: an initial evaluation of activity in one English primary care organisation

International Journal of Pharmacy Practice, 2018
Joe Bush, C. Langley, D. Jenkins, J. Johal, C. Huckerby   +4 more
semanticscholar   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Understanding the perspectives of people with dementia and family carers about clinical pharmacists in primary care: A qualitative study. [PDF]

PLoS One
Burnand A, Woodward A, Kantilal K, Bhanu C, Jani Y, Manthorpe J, Orlu M, Rait G, Sajid M, Samsi K, Vickerstaff V, Ward J, Wilcock J, Davies N.   +13 more
europepmc   +1 more source