Results 351 to 360 of about 9,870,305 (401)
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Clinical Pharmacology of Inodilators
Journal of Cardiovascular Pharmacology, 1989Recent advances in our knowledge of heart failure have shown that both a central and a peripheral factor are involved in this syndrome. Therefore, the ideal drug should combine the properties of a positive inotropic agent with those of a peripheral vasodilator; many drugs recently introduced into clinical practice have been shown to present both of ...
DEI CAS, Livio +2 more
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Emerging Applications of Metabolomics in Clinical Pharmacology
Clinical pharmacology and therapy, 2019Metabolic disturbances have been associated with many human diseases, including cancer, diabetes, and cardiovascular disease. Metabolomics, a rapidly growing member of the –omics family, investigates cellular metabolism by quantifying metabolites on a ...
Huanhuan Pang, Wei Jia, Zeping Hu
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Clinical Pharmacology of Lacidipine
Journal of Cardiovascular Pharmacology, 1991The safety and tolerability of lacidipine was assessed in a volunteer population, and its pharmacodynamic and pharmacokinetic profiles evaluated. In normotensive subjects, single oral doses of 3-5 mg of lacidipine produced a dose-related fall in peripheral vascular resistance.
S. T. Hall +4 more
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Rapacuronium: clinical pharmacology
European Journal of Anaesthesiology, 2001The need for a rapid-acting non-depolarizing neuromuscular blocking agent with a short duration of action resulted in the synthesis of rapacuronium. The onset of maximum block with rapacuronium occurs in 60-90 s with doses of 1.5-2.5 mg kg-1 with a duration of clinical relaxation of 15-30 min.
K. C. McCourt, Rajinder K. Mirakhur
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Expert Opinion on Drug Metabolism & Toxicology, 2019
Introduction: Triantennary N-acetyl galactosamine (GalNAc3) – conjugated antisense oligonucleotides (ASOs) have demonstrated improved hepatocyte uptake and pharmacologic activity over their parent unconjugated ASOs in animals and humans.
Yanfeng Wang, R. Yu, S. Henry, R. Geary
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Introduction: Triantennary N-acetyl galactosamine (GalNAc3) – conjugated antisense oligonucleotides (ASOs) have demonstrated improved hepatocyte uptake and pharmacologic activity over their parent unconjugated ASOs in animals and humans.
Yanfeng Wang, R. Yu, S. Henry, R. Geary
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Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review
The Journal of pharmacy and pharmacology, 2019Rosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments.
M. Akram +12 more
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Clinical pharmacology of etoricoxib
Expert Opinion on Drug Metabolism & Toxicology, 2005Etoricoxib is a highly selective COX-2 inhibitor (coxib) approved in Europe for the treatment of osteoarthritis (OA), rheumatoid arthritis and acute gouty arthritis. Etoricoxib is an effective analgesic drug that has shown some improved efficacy versus traditional NSAIDs and it is the only coxib approved for the treatment of acute gouty arthritis ...
CAPONE ML +2 more
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Clinical Pharmacology Of Caffeine
Annual Review of Medicine, 1990Caffeine is the most widely consumed stimulant drug in the world. This chapter reviews the human pharmacology of caffeine; the evidence for its role in causing human disease, including addiction; and its potential usefulness as a therapeutic agent.
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Clinical pharmacology and malaria
Annals of Tropical Medicine And Parasitology, 1997The role of clinical pharmacology in improving the prevention and treatment of malaria is reviewed. A series of general and specific issues is discussed, concentrating on risk-benefit and cost-effectiveness. The techniques of clinical pharmacokinetics play an important role in the optimal use of drugs and this is illustrated by studies on quinine and ...
Alasdair Breckenridge, P. A. Winstanley
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CLINICAL PHARMACOLOGY OF BENZODIAZEPINES
Annual Review of Medicine, 1987The benzodiazepines are the most widely used anxiolytic drugs. Their pharmacokinetic properties differ widely. Side effects are usually mild but dependence can supervene after long-term administration, even if normal therapeutic doses are not exceeded. Careful monitoring of use is essential.
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