Results 61 to 70 of about 308,843 (271)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives

BMC Chemistry, 2019
We have synthesized new series of bisindole analogs (1–27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ...
Muhammad Taha, Imad Uddin, Mohammed Gollapalli, Noor Barak Almandil, Fazal Rahim, Rai Khalid Farooq, Muhammad Nawaz, Mohamed Ibrahim, Mohammed A. Alqahtani, Yasser A. Bamarouf, Manikandan Selvaraj   +10 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Investigating the organisational factors associated with variation in clinical productivity in community pharmacies: a mixed-methods study

Health Services and Delivery Research, 2017
Background: Community pharmacies play a key role in health-care systems, dispensing prescriptions and providing medicine-related services. Service provision varies across community pharmacy organisations and may depend on organisational characteristics ...
Sally Jacobs, Fay Bradley, Rebecca Elvey, Tom Fegan, Devina Halsall, Mark Hann, Karen Hassell, Andrew Wagner, Ellen Schafheutle   +8 more
doaj   +1 more source

Strengthening the Free Healthcare Initiative through a pharmacy and supply chain intervention: Partners in Health's experience in rural Sierra Leone

The Lancet Global Health, 2017
Background: To improve high maternal and under-5 mortality—among the worst globally—Sierra Leone's Ministry of Health and Sanitation (MOHS) enacted the Free Healthcare Initiative in 2010.
Sheriff L Bangura, BPharm, Katrina Hann, MA, Ameet Salvi, BSc, Rebecca Kahn, BA, Kerry L Dierberg, MD, Joseph Gassimu, BSc, Alpha Kabbah, BPharm, Regan H Marsh, MD   +7 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Origins and history of global and Polish clinical pharmacy

Family Medicine & Primary Care Review
The history of global clinical pharmacy can be traced back to the second half of the 20th century. The initiators of the first efforts to disseminate the practice of clinical pharmacists were American pharmacists and American research centers.
Arkadiusz Adamiszak, Sylwia Adamiszak
doaj   +1 more source

Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study

BMC Chemistry, 2019
Background Indole based thiadiazole derivatives (1–22) have synthesized, characterized by NMR and HREI-MS and evaluated for β-Glucuronidase inhibition. All compounds showed outstanding β-glucuronidase activity with IC50 values ranging between 0.5 ± 0.08 ...
Noor Barak Almandil, Muhammad Taha, Mohammed Gollapalli, Fazal Rahim, Mohamed Ibrahim, Ashik Mosaddik, El Hassane Anouar   +6 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source