Results 221 to 230 of about 18,067,200 (315)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Safety of Intravenous Edaravone in Clinical Practice. [PDF]

Muscle Nerve
Genge A, Apple S.
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Harnessing Oxidative Stress to Kill Hepatocellular Carcinoma Cancer Cells: The Power of Methylselenic Acid and/or Pharmacological Ascorbate Combination—An In Vitro Study

Advances in Pharmacological and Pharmaceutical Sciences
Aseel O. Rataan, Amjad Z. Alrosan, Haneen A. Amawi, Lana Rababah, Osama Abo Alrob, Ayman T. Fazaa   +5 more
doaj   +1 more source

Pharmacist-driven antimicrobial stewardship: evolving roles in clinical practice. [PDF]

J Pharm Health Care Sci
Okada N.
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Deprescribing in Older People: A Clinical Practice Guideline Summary. [PDF]

Med J Aust
Quek HW, Reus Perello X, Lee K, Abraham A, Adams LA, Almeida OP, Almutairi H, Armstrong B, Boase L, Breen J, Brown LJ, Caughey GE, Chan LW, Chen R, Chew E, Clark A, Comans T, Criddle D, Dārziņš P, Dawda P, Doust JA, Edwards S, Gowan J, Hart K, Hawthorne D, Heredia A, Hill AM, Jansen J, Kalisch Ellett L, Keen H, Kelty EA, Kerse NM, Kruger E, Kurrle SE, Lance H, Livori A, Livori R, LoGiudice DC, Mangoni AA, Marinucci A, McKay N, Mckendrick AM, McLachlan AJ, McGuire TM, Mearns S, Morgan M, Nabi S, Naganathan V, Newman E, Ng CACM, Osborne M, Parkin R, Polkinghorne KR, Pond CD, Potter K, Rigby D, Rowett D, Schipp A, Seda V, Seeto J, Shakib S, Shiu A, Stafford AC, Tan IJ, Tennant M, Teoh L, Tucker S, Watson JDG, Wellins D, Whitmore T, Etherton-Beer C, Page AT.   +71 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The Efficacy of the Fitzpatrick Scale in Clinical Practice. [PDF]

HCA Healthc J Med
Olsen D, Nguyen C, Hall M, Carletti M, Weis SE.   +4 more
europepmc   +1 more source