Results 281 to 290 of about 5,065,330 (358)

Obesity care in Chinese adults: from evidence to clinical practice. [PDF]

Precis Clin Med
An J, Jia Q, Huang Y, Cao Y, Duan Y, Zhang H, Li S.   +6 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Genetic Variants in Liver Cirrhosis: Classifications, Mechanisms, and Implications for Clinical Practice. [PDF]

J Pers Med
Raghavan RP, Alexander KT, Sadasivan S, Parmar C, Kathirvel M.   +4 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Clinical Practice Guideline: Nonspecific Neck Pain. [PDF]

Dtsch Arztebl Int
El-Allawy A, Hecht N, Luedtke K, Schleicher P, Weidner N, Kötter T.   +5 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The hidden risk of round numbers and sharp thresholds in clinical practice. [PDF]

NPJ Digit Med
Lengerich BJ, Caruana R, Nunnally ME, Kellis M.   +3 more
europepmc   +1 more source

Management features of elderly and senile patients with non-ST elevation acute coronary syndrome in clinical practice

Е. В. Константинова, S. O. Denisova, A. D. Shcherbatsevich, Margarita Kalinina, Alexander Chernikov, N. A. Rahimi, A. A. Velikotsky, E. V. Ploshchenkov   +7 more
openalex   +2 more sources

[Residency training in clinical practice]. [PDF]

Radiologie (Heidelb)
Soltani M, Molwitz I, Notohamoprodjo M.
europepmc   +1 more source