Results 51 to 60 of about 2,133,135 (297)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

“Provoking conversations”: case studies of organizations where Option Grid™ decision aids have become ‘normalized’

BMC Medical Informatics and Decision Making, 2017
Background Implementing patient decision aids in clinic workflow has proven to be a challenge for healthcare organizations and physicians. Our aim was to determine the organizational strategies, motivations, and facilitating factors to the routine ...
Peter Scalia, Glyn Elwyn, Marie-Anne Durand   +2 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Collaborative care model for diabetes in primary care settings in Qatar: a qualitative exploration among healthcare professionals and patients who experienced the service

BMC Health Services Research, 2021
Background Diabetes mellitus is highly prevalent and associated with huge economic burden globally. The conventional care and management of diabetes mellitus is highly fragmented and complex, warranting the need for a comprehensive Collaborative Care ...
Sara Abdulrhim, Sowndramalingam Sankaralingam, Mohamed Izham Mohamed Ibrahim, Mohammed Issam Diab, Mohamed Abdelazim Mohamed Hussain, Hend Al Raey, Mohammed Thahir Ismail, Ahmed Awaisu   +7 more
doaj   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Assessment of knowledge, attitude, and practices of acute kidney injury incidence with co-administration of piperacillin/tazobactam and vancomycin among healthcare workers: A cross-sectional study

Saudi Pharmaceutical Journal, 2023
Background: No studies have identified a link between acute kidney injury (AKI) incidence due to the co-administration of vancomycin and piperacillin/tazobactam (VPT) and healthcare providers’ knowledge, attitudes, and practices.
Haytham A. Wali, Mohammed A. Alabdulwahed, Ghaida Y. Al-Hussain, Meaid A. Alabbad, Lojain H. Al-Khalaf, Sarah S. Alhumaidi, Khalid Alhussain, Sufyan M. Alomair, Abdulaziz S. Almulhim   +8 more
doaj  

Implementation and sustainability factors of two early-stage breast cancer conversation aids in diverse practices

Implementation Science, 2021
Background Conversation aids can facilitate shared decision-making and improve patient-centered outcomes. However, few examples exist of sustained use of conversation aids in routine care due to numerous barriers at clinical and organizational levels. We
Danielle Schubbe, Renata W. Yen, Catherine H. Saunders, Glyn Elwyn, Rachel C. Forcino, A. James O’Malley, Mary C. Politi, Julie Margenthaler, Robert J. Volk, Karen Sepucha, Elissa Ozanne, Sanja Percac-Lima, Ann Bradley, Courtney Goodwin, Maria van den Muijsenbergh, Johanna W. M. Aarts, Peter Scalia, Marie-Anne Durand   +17 more
doaj   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Knowledge and attitude of human Mpox viral infection among pharmacy students in Jazan University: a web based cross-sectional study

Frontiers in Public Health
IntroductionSaudi Arabia has witnessed the first confirmed case of Mpox on July 14th, 2022. Currently, there is no approved medication for the treatment of this infection. Therefore, prevention of this infection is crucial.
Eman Merghani Ali, Eman Merghani Ali, Amani Khardali, Amani Khardali, Nawazish Alam, Nawazish Alam, Abdulkarim M. Meraya, Abdulkarim M. Meraya, Hilal A. Thaibah, Hilal A. Thaibah, Dalin A. Hassan, Mohamed Eltaib Elmobark, Alanood Aladwani, Alanood Aladwani, Anugeetha Thacheril Mohanan, Hanan A. Bakri, Zamzam O. Mashraqi, Areej Mousa Salhabi   +17 more
doaj   +1 more source