Results 91 to 100 of about 10,236,771 (298)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Results of Cervical Cancer Patients Treated According to Clinical Practice Guidelines in Siriraj Hospital

Siriraj Medical Journal, 2003
Patients with cervical cancer stage Ib-IVa treated with curative intent at Siriraj Hospital between January and December 2002 were included in the study. There were 362 patients with an age range of 26-86 years old.
Nantakan Ieumwananonthachai, Pittayapoom Pataranutraporn, Yaowalak Chasilpa, Supatra Sangruchi, Vuttisiri Verasan, Nan Suntornpong, Janjira Petchsuksiri, Raweewan Vutipruk, Chatchapol Kietikajornthada, Nataya Samasanti, Nuchapong Noumtong   +10 more
doaj  

The Conundrum of Clinical Practice Guidelines

The Canadian Journal of Hospital Pharmacy, 2013
Clinical practice guidelines (CPGs) have been defined by the Institute of Medicine as “systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances”. The purported benefits of CPGs include improving patient outcomes, standardizing practice by ensuring a certain ...
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Myanmar Clinical Practice Guideline for Osteoporosis

Journal of the ASEAN Federation of Endocrine Societies, 2014
Osteoporosis is a disease in which the density and quality of bone are reduced, leading to weakness of the skeleton and increased risk of fracture, particularly of the spine, wrist and hip.
Than Than Aye, Ko Ko, Thein Myint, Ni Ni Hlaing, Myint Thaung, Tet Tun Chit   +5 more
doaj  

Improving Clinical Practice Guidelines [PDF]

JAMA Internal Medicine, 2014
According to a 2011 definition from the Institute ofMedicine, clinical practice guidelines provide “recommendations intended to optimize patient care,” and “are informed by a systematic reviewof evidence and an assessment of the benefits and harms of alternative care options.” It has been known for years that the quality of guidelines varies ...
openaire   +2 more sources

KDOQI clinical practice guideline for hemodialysis adequacy: 2015 update

, 2016
Guideline Summary "KDOQI clinical practice guideline for hemodialysis adequacy", 2015 ...
by National Kidney Foundation, transl. Dmytro D. Ivanov
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Diagnosis and staging of patients with ovarian cancer: National Clinical Guideline No. 20 Annex 1: Systematic review of cost effectiveness

, 2018
The purpose of this systematic review was to identify and evaluate economic evidence to inform the clinical recommendations of this NCG. Review of the cost-effectiveness of health technologies enables guideline developers to explicitly consider how ...
HRB-CICER (Collaboration in Ireland for Clinical Effectiveness Reviews)
core