Results 301 to 310 of about 3,299,699 (357)

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Adolopment of clinical practice guidelines and creation of referral pathways for dermatological conditions in Pakistan. [PDF]

Lancet Reg Health Southeast Asia
Pervez A, Nizam J, Baig MI, Ahmer A, Ghulam U, Martins RS, Khawaja A, Rizvi NA, Rehman AA, Mustafa MA, Ayub B, Aamdani SS, Raza S, Rukhsar S, Tabassum S, Amber T, Shariq SF, Nadeem S, Naveed S, Haider AH, Masood S.   +20 more
europepmc   +1 more source

2016 EUROPEAN GUIDELINES ON CARDIOVASCULAR DISEASE PREVENTION IN CLINICAL PRACTICE. THE SIXTH JOINT TASK FORCE OF THE EUROPEAN SOCIETY OF CARDIOLOGY AND OTHER SOCIETIES ON CARDIOVASCULAR DISEASE PREVENTION IN CLINICAL PRACTICE (CONSTITUTED BY REPRESENTATIVES OF 10 SOCIETIES AND BY INVITED EXPERTS)

, 2017
Editorial article
openalex   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Nationwide survey of adherence to the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024 in the initial management of sepsis. [PDF]

J Intensive Care
Oami T, Kasugai D, Yamakawa K, Matsuoka T, Kano K, Aoki Y, Yatabe T, Shime N, Nakada TA.   +8 more
europepmc   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Updating the Brazilian clinical practice guidelines for sickle cell disease: Recommendations and development process. [PDF]

Hematol Transfus Cell Ther
Gargano LP, Fachi MM, Oliveira LA, Lobo C, Melnikoff KNT, Soriano S, Maior MDCLS, Kron-Rodrigues MR, Gomes DF, Oliveira Junior HA, Lucchetta RC.   +10 more
europepmc   +1 more source

Osteocytes under Mechanical Loading Regulate PC‐3 Cancer Cell–Mineral Interactions during Early‐Stage Metastasis to Bone

Advanced Biology, EarlyView.
In this study, Seaman et al. develop a co‐culture assay to examine interactions between prostate cancer cells and mineralized osteoblasts in a microfluidic platform. The authors collect conditioned media from static or flow‐stimulated osteocytes and demonstrate that mechanical loading of osteocytes regulates the growth of prostate cancer cells and ...
Kimberly Seaman, Bryan Guo, William W. Du, Burton Yang, Yu Sun, Lidan You   +5 more
wiley   +1 more source

Implementing Clinical Practice Guidelines: Considerations for Epileptologists. [PDF]

Epilepsy Curr
Gutierrez C, Roberson SW, Esmaeili B, Punia V, Johnson EL.   +4 more
europepmc   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source