Results 31 to 40 of about 24,838 (241)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Main messages for primary care from the 2016 European Guidelines on cardiovascular disease prevention in clinical practice

European Journal of General Practice, 2018
In 2016, a new version of the European Guidelines on Cardiovascular Prevention was released, representing a partnership between the European Association for Cardiovascular Prevention and Rehabilitation of the European Society of Cardiology (ESC) and nine
Massimo F. Piepoli, Arno W. Hoes, Carlos Brotons, Richard F.D. Hobbs, Ugo Corra, on behalf of the Task Force for the 2016 guidelines on cardiovascular disease prevention in clinical practice   +5 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Bilan des études sur les guides de pratique en santé : qu’en retirer pour la santé et la sécurité au travail

Perspectives Interdisciplinaires sur le Travail et la Santé, 2012
The development and assessment of clinical practice guidelines has been the subject of numerous studies and analyses. Such guidelines are seen as an optimal way to ensure knowledge transfer and thereby disseminate and rationalize best practices.
Monique Lortie, Cheikh Faye, Elena Laroche, Lise Desmarais, Denys Denis, Iuliana Nastasia, Sylvie Gravel, Laurent Giraud   +7 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Investigation and Evaluation of Chinese Clinical Practice Guidelines Published in Medical Journals in 2019:Reporting Status of Abstract

Xiehe Yixue Zazhi, 2022
Objective  To investigate the reporting status of abstracts of Chinese clinical practice guidelines published in medical journals in 2019 and provide a reference for related researchers to write guideline abstracts and develop the reporting standard ...
REN Mengjuan, YANG Nan, LIU Yunlan, SUN Yajia, SHI Qianling, ZHOU Qi, WANG Zijun, CHEN Yaolong   +7 more
doaj   +1 more source

Clinical Practice Guidelines for Achondroplasia*

Clinical Pediatric Endocrinology, 2020
Achondroplasia (ACH) is a skeletal dysplasia that presents with limb shortening, short stature, and characteristic facial configuration. ACH is caused by mutations of the FGFR3 gene, leading to constantly activated FGFR3 and activation of its downstream intracellular signaling pathway.
Taichi Kitaoka, Masanori Adachi, Makoto Fujiwara, Takuo Kubota, Yasuhisa Ohata, Keiichi Ozono, Toshimi Michigami, Hiroshi Mochizuki, Kosei Hasegawa   +8 more
openaire   +4 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Interpretation on the Chinese Clinical Practice Guidelines for Hypertension: Key points of nursing practice and management strategies [PDF]

Jichu yixue yu linchuang
In September 2024, the updated version of Chinese Clinical Practice Guidelines for Hypertension was published. This version of guidelines comprises 44 pivotal clinical inquiries and 99 recommendations pertaining to the diagnosis, assessment, and ...
LI Yingxia, LI Wenming, YU Qiuhua, WU Nan
doaj   +1 more source