Results 21 to 30 of about 6,182 (178)
Presentation of SLE in UK primary care using the Clinical Practice Research Datalink [PDF]
Lupus Science & Medicine, 2017 Objectives To describe the presenting symptoms of SLE in primary care using the Clinical Practice Research Database (CPRD) and to calculate the time from symptom presentation to SLE diagnosis. Methods Incident cases of SLE were identified from the ...
Nightingale, Alison +4 more
openaire +3 more sources
International Journal of Population Data Science, 2017 Objectives To enhance the research value and capability of its primary care database, the Clinical Practice Research Datalink (CPRD) has collaborated with Public Health England (PHE)’s National Cancer Registration and Analysis Service to facilitate ...
Sophia Amjad +4 more
doaj +1 more source
International Journal of Population Data Science, 2017 Objective Linked electronic healthcare databases are increasingly being used in observational research. The objective of this study was to investigate the impact of the choice of data source in estimating mortality following VTE, with a secondary aim to ...
Arlene Gallagher +2 more
doaj +1 more source
Supplementing linked datasets with meaningful meta-data to enable high quality research
International Journal of Population Data Science, 2017 Objectives Enable high quality research using linked data sources whose membership and coverage change over time by providing clarity in applied processing steps and meaningful meta-data.
Shivani Padmanabhan +2 more
doaj +1 more source
BJGP Open, 2021 Background: Previous work has demonstrated that the recording of acute health outcomes, such as myocardial infarction (MI), may be suboptimal in primary healthcare databases.
Ann Morgan +4 more
doaj +1 more source
Domperidone use and risk of primary liver cancer in the Clinical Practice Research Datalink [PDF]
Cancer Epidemiology, 2018 Pronounced sex-disparity in liver cancer suggests a role for hormones, one of which could be prolactin. Stimulation of prolactin production in mice via domperidone has been reported to decrease hepatocarcinogenesis, thus may have chemopreventive potential.
Jake E, Thistle +5 more
openaire +2 more sources
Statin Use and Risk of Primary Liver Cancer in the Clinical Practice Research Datalink [PDF]
JNCI Journal of the National Cancer Institute, 2015 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are widely prescribed to reduce cholesterol levels. Studies have suggested that statins are associated with reduced risk of liver cancer, but much of the evidence is from regions of the world with high liver cancer incidence rates.
Katherine A, McGlynn +6 more
openaire +2 more sources
Mortality rates in people with intellectual disabilities
International Journal of Population Data Science, 2017 Objectives A growing body of evidence highlights a disparity in mortality rates for people with intellectual disability (ID) compared with the general population. However, national data for England is lacking.
Rachael Williams +3 more
doaj +1 more source
BMJ Open, 2020 Objective To identify observational studies which used data from more than one primary care electronic health record (EHR) database, and summarise key characteristics including: objective and rationale for using multiple data sources; methods used to ...
Rachael Williams +5 more
doaj +1 more source
The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink [PDF]
Clinical Rheumatology, 2018 To estimate the incidence, prevalence, and survival of systemic sclerosis in the United Kingdom. We conducted a historical cohort study using data from the Clinical Practice Research Datalink (CPRD). We calculated the incidence and survival of systemic sclerosis between 1994 and 2013 and examined its association with age, sex, and socioeconomic status.
Jeremy G. Royle +4 more
openaire +3 more sources