Results 41 to 50 of about 6,182 (178)

The accuracy of death dates recorded in the Clinical Practice Research Datalink (CPRD)

Pharmacoepidemiology and Drug Safety, 2017
CPRD provides general practice (GOLD) data linked to several other datasets. This can reveal discrepancies in key outcomes where similar data is available in two linked data sources. We explored discrepancies between death date recorded in the GOLD dataset and linked ONS national mortality data.
Harshfield, A, Rhodes, K, Barclay, S, Payne, R   +3 more
openaire   +3 more sources

An algorithm to improve diagnostic accuracy in diabetes in computerised problem orientated medical records (POMR) compared with an established algorithm developed in episode orientated records (EOMR)

Journal of Innovation in Health Informatics, 2015
An algorithm that detects errors in diagnosis, classification or coding of diabetes in primary care computerised medial record (CMR) systems is currently available.  However, this was developed on CMR systems that are “Episode orientated” medical records
Simon de Lusignan, Siaw-Teng Liaw, Daniel Dedman, Kamlesh Khunti, Khaled Sadek, Simon Jones   +5 more
doaj   +1 more source

Associations of Sleep and Shift Work with Osteoarthritis Risk

Arthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Costs of Gastrointestinal Bleeding Events in Atrial Fibrillation: A Uk Clinical Practice Research Datalink Study [PDF]

Future Cardiology, 2019
Aim: To estimate the healthcare costs attributable to gastrointestinal (GI) bleeds in nonvalvular atrial fibrillation (NVAF) patients. Material & methods: A difference-in-differences approach was used in which NVAF patients suffering a (GI) bleed were propensity score matched to those not suffering a GI bleed, and the difference in healthcare costs in ...
Sreeram V Ramagopalan, Mihail Samnaliev, Sharada Weir, Cormac J Sammon, Robert Carroll, Raza Alikhan   +5 more
openaire   +2 more sources

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, EarlyView.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study [PDF]

BMJ Open, 2015
Objective Rheumatoid arthritis (RA) is a multisystem, inflammatory disorder associated with increased levels of morbidity and mortality. While much research into the condition is conducted in the secondary care setting, routinely collected primary care databases provide an important source of research data.
Müller, S, Hider, SL, Raza, K, Stack, RJ, Hayward, RA, Mallen, CD   +5 more
openaire   +3 more sources

Drug‐Induced Raynaud's Phenomenon and Underlying Mechanism: A Disproportionality Analysis From the World Health Organization Pharmacovigilance Database

Arthritis &Rheumatology, EarlyView.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Prescribing of medication to prevent glucocorticoid harms in patients with Polymyalgia Rheumatica: a cross‐sectional study and two emulated target trials in the Clinical Practice Research Datalink Aurum

Arthritis &Rheumatology, Accepted Article.
Objectives Polymyalgia rheumatica (PMR) is a common indication for long‐term glucocorticoid (GC) treatment. Bone‐ and gastro‐protective medications are recommended for those at high‐risk of adverse events from GCs but no trials have evaluated their effectiveness in PMR.
Helen Twohig, David Jenkinson, James Bailey, Samantha Hider, Ian C Scott, Sara Muller   +5 more
wiley   +1 more source

Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink [PDF]

Journal of Investigative Dermatology, 2015
The association between psoriasis and risk of major cardiovascular (CV) events (myocardial infarction, acute coronary syndrome, unstable angina, and stroke) is unclear. A cohort study with 48,523 patients with psoriasis and 208,187 controls was conducted. During a median follow-up of 5.2 years, 1,257 patients with psoriasis (2.59%) had a major CV event,
Parisi, Rosa, Rutter, Martin K, Lunt, Mark, Young, Helen S, Symmons, Deborah P M, Griffiths, Christopher E M, Ashcroft, Darren M   +6 more
openaire   +3 more sources

Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

Respiratory Research, 2018
Background To evaluate the adverse events profile of oral prednisolone among adult asthma patients in the UK. Methods Using data from the UK-based Clinical Practice Research Datalink, we conducted a series of cohort studies to quantify incidence rates ...
Marlene Bloechliger, Daphne Reinau, Julia Spoendlin, Shih-Chen Chang, Klaus Kuhlbusch, Liam G. Heaney, Susan S. Jick, Christoph R. Meier   +7 more
doaj   +1 more source