Results 61 to 70 of about 6,182 (178)

Non-adherence to medications prescribed to patients with heart failure in general practice: prevalence, risk factors and association with mortality and hospitalisation

Open Heart
Aim In the UK, pharmacological management of patients with heart failure (HF) occurs predominantly in general practice. Using data from the Clinical Practice Research Datalink, we examined the prevalence and risk factors for medication non-adherence and ...
Alex Bottle, Jamil Mayet, Tarita Murray-Thomas, Puja Myles   +3 more
doaj   +1 more source

PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term – a cluster randomised controlled trial and economic evaluation

Health Technology Assessment, 2016
Background: Asthma episodes and deaths are known to be seasonal. A number of reports have shown peaks in asthma episodes in school-aged children associated with the return to school following the summer vacation.
Steven A Julious, Michelle J Horspool, Sarah Davis, Mike Bradburn, Paul Norman, Neil Shephard, Cindy L Cooper, W Henry Smithson, Jonathan Boote, Heather Elphick, Amanda Loban, Matthew Franklin, Wei Sun Kua, Robin May, Jennifer Campbell, Rachael Williams, Saleema Rex, Oscar Bortolami   +17 more
doaj   +1 more source

Measurement and management of adult blood pressure in the peri‐operative period: updated guidelines from the Association of Anaesthetists and the British and Irish Hypertension Society

Anaesthesia, Volume 81, Issue 3, Page 402-414, March 2026.
Summary Introduction Maintaining stable blood pressure during surgery is a key responsibility of anaesthetists. Peri‐operative omission and reintroduction of antihypertensive drugs, general anaesthesia, neuraxial and regional techniques can all cause significant fluctuations in blood pressure, particularly in patients with hypertension. Since the first
Terry McCormack, Alex Wickham, Sinéad T. J. McDonagh, Matthew D. Wiles, Luca Faconti, Rachael Brooks, Simon G. Anderson, Andrew Hartle   +7 more
wiley   +1 more source

The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink [PDF]

Rheumatology, 2016
To estimate the incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK.We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Episode Statistics (HES). We calculated incidence rate ratios, adjusted for age, gender and ethnicity, using Poisson regression.We identified 462 ...
Pearce, Fiona A., Grainge, Matthew J., Lanyon, Peter C., Watts, Richard A, Hubbard, Richard B.   +4 more
openaire   +3 more sources

Pooling of primary care electronic health record (EHR) data on Huntington’s disease (HD) and cancer: establishing comparability of two large UK databases

BMJ Open
Objectives To explore whether UK primary care databases arising from two different software systems can be feasibly combined, by comparing rates of Huntington’s disease (HD, which is rare) and 14 common cancers in the two databases, as well as ...
Rachael Williams, Krishnan Bhaskaran, Ian J Douglas, Daniel Dedman   +3 more
doaj   +1 more source

Literature‐informed ensemble machine learning for three‐year diabetic kidney disease risk prediction in type 2 diabetes: Development, validation, and deployment of the PSMMC NephraRisk model

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1997-2026, March 2026.
Abstract Introduction Diabetic kidney disease (DKD) and diabetic nephropathy (DN) affect around 40% of diabetic patients but lack accurate risk prediction tools that include social determinants and demographic complexity. We developed and validated an ensemble machine learning model for three‐year DKD/DN risk prediction with deployment readiness ...
Ayla M. Tourkmani, Turki J. Al‐Harbi, Ahmad Abdullah Alghamdi, Ibrahim M. Youzghadli, Faris Saad Alosaimi, Ahmed Y. Azzam   +5 more
wiley   +1 more source

Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study

Health Technology Assessment, 2019
Background: Unnecessary prescribing of antibiotics in primary care is contributing to the emergence of antimicrobial drug resistance. Objectives: To develop and evaluate a multicomponent intervention for antimicrobial stewardship in primary care, and to ...
Martin C Gulliford, Dorota Juszczyk, A Toby Prevost, Jamie Soames, Lisa McDermott, Kirin Sultana, Mark Wright, Robin Fox, Alastair D Hay, Paul Little, Michael Moore, Lucy Yardley, Mark Ashworth, Judith Charlton   +13 more
doaj   +1 more source

Long‐acting insulin analogues and the risk of diabetic nephropathy among patients with type 2 diabetes: A population‐based cohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 2113-2122, March 2026.
Abstract Aims The risk of diabetic nephropathy among patients with type 2 diabetes (T2D) can be reduced through optimal glycaemic control. It is not known if the pharmacological properties of long‐acting insulin analogues may reduce the risk of diabetic complications compared with neutral protamine Hagedorn (NPH) insulin.
Julia Brillinger, Christopher Filliter, Shahrzad Salmasi, Estefania Zapata‐Bravo, Robert W. Platt, Oriana H. Y. Yu, Kristian B. Filion   +6 more
wiley   +1 more source

Persistence and compliance with osteoporosis therapies among postmenopausal women in the UK Clinical Practice Research Datalink [PDF]

Osteoporosis International, 2019
Gaining full benefits from osteoporosis medications requires long-term treatment. Investigating the real-world persistence of women receiving osteoporosis medications in the UK, we found that most patients stop treatment within a year. To prevent osteoporotic fragility fractures, long-term treatment persistence must be improved.Persistence with ...
J. Morley, A. Moayyeri, L. Ali, A. Taylor, M. Feudjo-Tepie, L. Hamilton, J. Bayly   +6 more
openaire   +2 more sources

Trends in first‐line monotherapy and combination therapy for hypertension in UK primary care

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 457-467, February 2026.
Aims Debate remains about the optimal initial treatment strategy for hypertension. Most guidelines recommend first‐line combination therapy for most patients. However, the UK's National Institute for Health and Care Excellence recommends first‐line monotherapy for all patients.
Kyle Johnson, Sarah Beradid, James M. Brophy, Robert W. Platt, Christel Renoux   +4 more
wiley   +1 more source