Results 71 to 80 of about 6,182 (178)

Use of multiple inflammatory marker tests in primary care: using Clinical Practice Research Datalink to evaluate accuracy [PDF]

British Journal of General Practice, 2019
BackgroundResearch comparing C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and plasma viscosity (PV) in primary care is lacking. Clinicians often test multiple inflammatory markers, leading to concerns about overuse.AimTo compare the diagnostic accuracies of CRP, ESR, and PV, and to evaluate whether measuring two inflammatory markers ...
Watson, J, Jones, HE, Banks, J, Whiting, P, Salisbury, C, Hamilton, W   +5 more
openaire   +4 more sources

Use of the CPRD Aurum Database: Insights Gained from New Data Quality Assessments

Clinical Epidemiology, 2023
Susan Jick,1,2 Catherine Vasilakis-Scaramozza,1 Rebecca Persson,1 David Neasham,3 George Kafatos,3 Katrina Wilcox Hagberg1 1Epidemiology, Boston Collaborative Drug Surveillance Program, Lexington, MA, USA; 2Epidemiology, Boston University School of ...
Jick S, Vasilakis-Scaramozza C, Persson R, Neasham D, Kafatos G, Hagberg KW   +5 more
doaj  

Effectiveness of Indapamide Prolonged‐Release and Perindopril Versus Perindopril Monotherapy for Treated Uncontrolled Hypertension: A Target Trial Emulation

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 2, February 2026.
ABSTRACT Objective To assess the effectiveness of indapamide prolonged release and perindopril in combination using blood pressure (BP) records collected in routine practice. Methods Using a target trial emulation framework, an observational retrospective cohort study was conducted.
Céline Darricarrere, Virginie Simon, Manel Pladevall‐Vila, Emmanuelle Jacquot, Morgane Ballon, Marie Mangin, Dominique Procureur, Jaume Aguado, Xabier Garcia‐Albeniz   +8 more
wiley   +1 more source

Recognising Kawasaki disease in UK primary care: a descriptive study using the Clinical Practice Research Datalink [PDF]

British Journal of General Practice, 2014
Kawasaki disease is a rare childhood illness that can present non-specifically, making it a diagnostic challenge. The clinical presentation of Kawasaki disease has not been previously described in primary care.To describe how children with an eventual diagnosis of Kawasaki disease initially present to primary care in the UK.The Clinical Practice ...
Moore, A, Harnden, A, Mayon-White, R
openaire   +2 more sources

Assessing data quality from the Clinical Practice Research Datalink: a methodological approach applied to the full blood count blood test

Journal of Big Data, 2020
A Full Blood Count (FBC) is a common blood test including 20 parameters, such as haemoglobin and platelets. FBCs from Electronic Health Record (EHR) databases provide a large sample of anonymised individual patient data and are increasingly used in ...
Pradeep S. Virdee, Alice Fuller, Michael Jacobs, Tim Holt, Jacqueline Birks   +4 more
doaj   +1 more source

Performance of the Self‐Controlled Case Series for Drug Safety Signal Detection: A Multi‐Database Study

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 2, February 2026.
ABSTRACT Background Differences in performance of the Self‐Controlled Case Series (SCCS) for signal detection have been reported across different databases. However, there has been limited comparative analysis of performance and it remains unknown whether combinations of databases could enable more effective signal detection. Objectives This study aims
Astrid Coste, Angel Y. S. Wong, Francois Haguinet, Andrew Bate, Ian J. Douglas   +4 more
wiley   +1 more source

Comparison of Rheumatoid Arthritis Information Recorded in UK CPRD Aurum and CPRD GOLD Databases (Companion Paper 3)

Clinical Epidemiology, 2023
Catherine Vasilakis-Scaramozza,1 Katrina Wilcox Hagberg,1 Rebecca Persson,1 George Kafatos,2 Joe Maskell,2 David Neasham,2 Susan Jick1,3 1Epidemiology, Boston Collaborative Drug Surveillance Program, Lexington, MA, USA; 2Center for Observational Research,
Vasilakis-Scaramozza C, Hagberg KW, Persson R, Kafatos G, Maskell J, Neasham D, Jick S   +6 more
doaj  

Identification of mental health and quality of life outcomes in primary care databases in the UK: a systematic review

BMJ Open, 2019
Objectives To summarise the definitions and combinations of codes used to identify outcomes of anxiety, depression, fatigue, cognitive dysfunction (including mild cognitive dysfunction and dementia), sexual dysfunction, pain, sleep disorders, and fatal ...
Rachael Williams, Helen Strongman, Helena Carreira, Krishnan Bhaskaran   +3 more
doaj   +1 more source

Sodium glucose co‐transporter 2 inhibitors versus dipeptidyl peptidase‐4 inhibitors and the risk of ventricular arrhythmia among patients with type 2 diabetes: A population‐based cohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 935-945, February 2026.
Abstract Aims To determine whether sodium glucose co‐transporter 2 inhibitors (SGLT2i) use, compared with dipeptidyl peptidase‐4 inhibitors (DPP4i) use, is associated with the risk of ventricular arrhythmias (VA) among patients with type 2 diabetes. Materials and Methods We conducted a population‐based cohort study using a prevalent new‐user design and
Wang‐Choi Tang, Pauline Reynier, Antonios Douros, Oriana H. Y. Yu, Robert W. Platt, Kristian B. Filion   +5 more
wiley   +1 more source

Treatment of first-time traumatic anterior shoulder dislocation: the UK TASH-D cohort study

Health Technology Assessment, 2019
Background: Shoulder dislocations are the most common joint dislocations seen in emergency departments. Most traumatic cases are anterior and cause recurrent dislocations. Management options include surgical and conservative treatments.
Jonathan L Rees, Anjali Shah, Katherine Edwards, Maria T Sanchez-Santos, Danielle E Robinson, Antonella Delmestri, Andrew Carr, Nigel Arden, Sarah E Lamb, Amar Rangan, Andrew Judge, Rafael Pinedo-Villanueva, Tim Holt, Sally Hopewell, Daniel Prieto-Alhambra, Gary Collins   +15 more
doaj   +1 more source