Results 161 to 170 of about 15,843,136 (243)

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Dual knowledge-guided data augmentation for robust clinical prediction models. [PDF]

Sci Rep
Moon S, Park PG, Choi N, Kim JH, Lim SH, Lee JH, Park MJ, Baek HS, Cho MH, Lee KH, Shin JI, Han KH, Kim JY, Song JY, Yang EM, Kim SH, Ahn YH, Kang HG, Park E.   +18 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Adaptive Gaussian process search for simulation-based sample size estimation in clinical prediction models: validation of the pmsims R package. [PDF]

BMC Med Res Methodol
Olaniran OR, Shamsutdinova D, Markham S, Zimmer F, Stahl D, Forbes G, Carr E.   +6 more
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Critical appraisal of fairness metrics for artificial intelligence-based clinical prediction models: a scoping review. [PDF]

Lancet Digit Health
Matos J, Van Calster B, Celi LA, Dhiman P, Gichoya JW, Riley RD, Russell C, Khalid S, Collins GS.   +8 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Ensuring Safe and Responsible Use of Artificial Intelligence in Medical Imaging: Pitfalls and Practical Solutions through the Lens of Obstetric Ultrasound

Indian Journal of Radiology and Imaging
Rishika Chanian, Ramachandran Thiruvengadam, Bapu Koundinya Desiraju   +2 more
doaj   +1 more source

Dissecting the pathobiology of suspected sepsis through a comparative analysis of endothelial inflammatory and clinical prediction models. [PDF]

Sci Rep
Ningthoujam AS, Thiyagarajan G, Wani NA, Sharma S, Chen KF, Nandi A.   +5 more
europepmc   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source