Results 71 to 80 of about 15,843,136 (243)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Emerging opportunities and challenges for clinical prediction models in psychiatry [PDF]

Clinical prediction models use individual-level patient data to inform clinical decisions across medicine. However, few are currently used in psychiatry.

core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

AI-based decision models for difficult airway assessment: from research innovation to clinical implementation—a narrative review

Frontiers in Medicine
Difficult airway management causes significant anesthesia-related morbidity, yet traditional assessments lack sensitivity (30%−50%) and consistency.
Yang Shen, Yang Shen, Yulan Wu, Yuwei Qiu, Jingxiang Wu   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

From chronic kidney disease classification to genuine early prediction: a systematic review of artificial intelligence, methodological quality, and translational evidence

Frontiers in Artificial Intelligence
IntroductionArtificial intelligence has been widely applied to chronic kidney disease (CKD), but the term ‘prediction” is frequently used for tasks ranging from contemporaneous disease classification to genuine forecasting of future renal outcomes.
Aminu Bashir Suleiman, Aminu Bashir Suleiman, Ahmad Tijjani Garba, Ahmad Tijjani Garba, Aisha Mustapha Ahmad, Kaloma Usman Majikumna, Harisu Abdullahi Shehu, Huseyin Kusetogullari   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Clinical and gait parameters used in sarcopenia prediction models.

Clinical and gait parameters used in sarcopenia prediction models.
Minkyeong Kim (213292), Shinjune Kim (17720726), Doeon Kim (630958), Seongjin Park (279953), Heeyoung Kang (4336150), Jun-Il Yoo (6317567)   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source