Results 241 to 250 of about 2,012,129 (303)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Perceptions of concussion management and testing among healthcare professionals in rugby union: a qualitative analysis. [PDF]

BMJ Open Sport Exerc Med
Palmer JL, Baker R, Regardsoe A, Irwin G, Williams G.   +4 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The "Asian Paradox" in multiple primary lung cancer: a geographic monopole driven by phenotypic divergence. [PDF]

NPJ Prim Care Respir Med
Shi J, Gao Y.
europepmc   +1 more source

Simplified versus traditional citrate anticoagulation in hemodialysis: Impact on clinical efficacy and patient prognosis, and correlative analysis. [PDF]

Medicine (Baltimore)
Wang Y, Yang J, Wu C.
europepmc   +1 more source

International Guidelines on Conscious Sedation in Pediatric Dentistry: A Comparative Analysis and Evidence Mapping Study. [PDF]

J Clin Med
Marques C, Dinis M, Botelho J, Machado V, Bandeira Lopes L.   +4 more
europepmc   +1 more source

Practical Challenges for the Implementation of AI-Based Image Analysis in Ophthalmology Research: Insights and Recommendations from a Swiss Multicentric Study. [PDF]

Klin Monbl Augenheilkd
Spitznagel T, Garweg JG, Eandi C, Grimaldi G, Menghini M, Ambresin A, Zweifel S, Somfai GM.   +7 more
europepmc   +1 more source

National Clinical Protocols

, 2018
Curajos, B.M., Bernic, J.V., Celac, V.I., Dzero, V.G., Curajos, A., Roller, V.G., Zaharia, I., Gheţeul, E., Seu, L., Revenco, A.M.   +9 more
openaire   +1 more source

Ongoing clinical protocols.

Ochsner journal, 2012
openaire   +1 more source