Results 191 to 200 of about 10,267,908 (249)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Appointment as Editor-in-Chief of Clinical Research in Cardiology-goals and vision. [PDF]

Clin Res Cardiol
Laufs U.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Operationalizing Large Language Models for Clinical Research Data Extraction: Methods, Quality Control, and Governance. [PDF]

J Med Syst
Chen L, He R, Lu P, Jin Y, Zhou L, Li N, Wu P, Hu B.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Strengthening clinical research and practice in China's healthcare system: a decade of action via the NEJM pilot initiative. [PDF]

Med Rev (2021)
Li P, Zhao J, Zhu S, Xiao RP.
europepmc   +1 more source

N-of-1 trials in clinical research: Methodological foundations, statistical approaches and implementation challenges. [PDF]

Br J Clin Pharmacol
De Carvalho MCL, de Matos Dourado Simões M, Adler UC, Junior ABV, de Sousa CNS, Sanders LLO.   +5 more
europepmc   +1 more source

Informed consent: Navigating the bioethical complexities of clinical research. [PDF]

Bioinformation
Waykar R, Kulkarni YA.
europepmc   +1 more source