Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Modeling integration: co-teaching basic and clinical sciences medicine in the classroom. [PDF]
Adv Med Educ Pract, 2018 Willey JM, Lim YS, Kwiatkowski T.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Perceptions of co-teaching as a pedagogical approach to integrate basic and clinical sciences. [PDF]
Front Med (Lausanne)Rodríguez-Martín I +6 more
europepmc +1 more source
Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences. [PDF]
Neuropsychopharmacology, 2019 Grillon C +3 more
europepmc +1 more source
Institute of Clinical and Translational Sciences News, August-September 2012 [PDF]
, 2012 core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Deciphering angiotensin converting enzyme 2 (ACE2) inhibition dynamics: Carnosine's modulatory role in breast cancer proliferation - A clinical sciences perspective. [PDF]
HeliyonMelhem SA +5 more
europepmc +1 more source