Results 201 to 210 of about 6,034,431 (246)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Needling Therapy for Burn Injury and Related Complications: A Scoping Review of Experimental and Clinical Studies. [PDF]

Int Wound J
Kim SA, Kang JW, Kim TH.
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Sodium and potassium intake in rheumatoid arthritis: a systematic review of clinical studies with implications for disease-related outcomes. [PDF]

Rheumatol Int
Anyfanti P, Antza C, Tragiannidis K, Belančić A, Şener YZ, Faour AK, Ainatzoglou A, Angeloudi E, Chaida E, Dimitroulas T, Kotsis V.   +10 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Editorial: Dysfunctional motivation in eating behaviors: a complex gene x environment interplay

Frontiers in Behavioral Neuroscience
Kirrilly Pursey, Kirrilly Pursey, Lucy Babicola, Lucy Babicola, Rossella Ventura, Rossella Ventura, Matteo Di Segni, Matteo Di Segni   +7 more
doaj   +1 more source

Natural language processing to enhance rheumatoid arthritis care in clinical studies: a scoping review of applications, data, approaches, challenges and future directions. [PDF]

Rheumatol Int
Huang Y, Agarwal SK.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Growth Hormone and Brain Regeneration: Evidence from Clinical Studies in Dementia, Traumatic Brain Injury, and Stroke: A Systematic Review. [PDF]

Int J Mol Sci
Bianchi VE, Visbal LC, Devesa J.
europepmc   +1 more source

Stochastic Approximator of Motor Threshold (SAMT) for Transcranial Magnetic Stimulation: Online Software and Its Performance in Clinical Studies. [PDF]

Transcranial Magn Stimul
Wang B, Shah VU, Koponen LM, Neacsiu AD, Daskalakis ZJ, Fitzgerald PB, Appelbaum LG, Choi JY, Gerlus N, Li Y, Hadas I, Sun Y, Poorganji M, Daniels H, Rodriguez K, Gotsis ES, Bailey NW, Raveendran J, Brinley SK, Gallo AT, Goetz SM, Peterchev AV.   +21 more
europepmc   +1 more source