Results 81 to 90 of about 6,934,145 (250)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Supervisor de psicologia clínica: um professor idealizado?

Psico-USF
A supervisão de estágios em Psicologia Clínica, fundamental para a formação do aluno de Psicologia, carece de mecanismos de avaliação sistemática, relativa ao supervisor.
Nancy Ramacciotti de Oliveira-Monteiro, Maria Lucia Tiellet Nunes   +1 more
doaj  

IMPLEMENTASI SUPERVISI KLINIS DALAM MENINGKATKAN EFEKTIVITAS PEMBELAJARAN DI SEKOLAH DASAR

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2016
The objective of this paper is to discover the implementation of clinical supervision for improving learning effectiveness towards sport, physical, and health education in SDIT Bumi Darun Najah Lekok District Pasuruan.
Ika Nova Margariena, Achmad Supriyanto, Burhanuddin Burhanuddin   +2 more
doaj   +1 more source

Barriers and Facilitators to Clinical Supervision in Ghana: A Scoping Review. [PDF]

SAGE Open Nurs
Background Clinical supervision involves the professional relationship between an experienced and knowledgeable clinician and a less experienced clinician in which the experienced clinician provides support toward the skills development of the less ...
Awiagah SK, Dordunu R, Hukporti N, Nukunu PE, Dzando G.   +4 more
europepmc   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The supervision needs of senior clinical psychologists [PDF]

, 2021
Section A This review critically evaluates the published literature regarding what sustains clinical psychologists in their careers over time. A systematic literature search of three online databases (PsychInfo, Assia and Web of Science) and a manual ...
Deegan, C.
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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

«The good learning situation» – student perspective on learning in clinical placement

Fysioterapeuten, 2012
Introduction: Learning in clinical placement is a core element in development of competent and independent physiotherapists. Knowledge about learning processes in clinical placement is important to universities and workplaces in organizing of clinical ...
Anne Kari Skøien, Unni Vågstøl
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Video-conferencing clinical supervision of rural, remote and northern counsellors to mitigate compassion fatigue

, 2020
This is a mixed methods quantitative-qualitative explanatory sequential research project informed by transformative and feminist epistemology. It investigates the patterns of engagement in clinical supervision among Canadian professional counsellors ...
Slipp, Micheala
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