Results 321 to 330 of about 13,113,839 (405)

The TB vaccine clinical trial centre directory: An inventory of clinical trial centres in Sub-Saharan Africa. [PDF]

PLoS One
Pelzer PT, Holleman M, Helinski MEH, Weinberg AL, Buis J, Beattie P, Nyirenda T, van Rest J, Voss G.   +8 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Clinical trials with the single-application fertility-regulating device

, 1977
Robert S. Neuwirth, Ralph M. Richart, Lee R. Bolduc   +2 more
openalex   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

AI meets informed consent: a new era for clinical trial communication. [PDF]

JNCI Cancer Spectr
Waters M.
europepmc   +1 more source

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

, 1977
Richard Peto, M. C. Pike, P. Armitage, N. E. Breslow, DUNCAN COX, S V Howard, Nathan Mantel, Kerri McPherson, Julian Peto, Peter G. Smith   +9 more
openalex   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

FEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla, Faiza Abbas, Luigia Rossi, Mauro Magnani, Sara Biagiotti   +4 more
wiley   +1 more source

A functional enzymatic assay as potential readout for a clinical trial of a schistosomiasis vaccine. [PDF]

NPJ Vaccines
Kifle DW, Balkhi MY, Ono Y, Davis J, Doi N, Arya A, Kim J, Kalyanasundaram A, Nandy S, Rakotozandrindrainy N, Staker B, Craig J, Rakotozandrindrainy R, Tadesse BT, Marks F, Jackson L, Carter D, Gray SA, Siddiqui AA.   +18 more
europepmc   +1 more source

Clinical trials in private clinics

Perspectives in Clinical Research, 2011
openaire   +3 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source