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Clinical trials

Frontiers in Bioscience, 2006
A clinical trial is a research study in human patients aimed at answering specific health questions. If a clinical trial is well-conducted, it is the fastest way to find treatments that work in people and ways to improve health. A clinical trial is one of the final stages of a long research process.
GIACINTI L., LOPEZ M., GIORDANO A.
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Clinical trials

Seminars in Surgical Oncology, 1996
The randomized clinical trial is a scientific method for solving clinical problems. The method is typically employed before a new type of treatment is offered on a major scale in order to safeguard patients against a less curative therapy. Especially with regard to cancer treatment, randomized studies are conducted in increasing numbers. However, there
M, Blichert-Toft   +2 more
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Preserving Clinical Trial Integrity During the Coronavirus Pandemic.

Journal of the American Medical Association (JAMA), 2020
Randomized clinical trials provide the highestquality evidence for identifying therapies to help people attain longer and healthier lives. As of March 2020, ClinicalTrials.gov listed 262 366 ongoing randomized clinical trials, including 146 420 trials ...
M. McDermott, A. Newman
semanticscholar   +1 more source

The Trials of Clinical Trials

Archives of Neurology, 1989
Controlled clinical trials are becoming increasingly frequent in neurology. A review of the literature indicates that several trials have serious flaws in study design and conduct that render the results questionable or uninterpretable. These reports, together with my own experience with the trial of plasmapheresis in the treatment of acute Guillain ...
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The Clinical Trial

The Milbank Memorial Fund Quarterly. Health and Society, 1981
This paper argues that scientific clinical trials are the most ethical way to benefit patients whenever there is uncertainty about proper diagnosis and therapy. An increasing number of trials reported in clinical journals have employed randomization since the 1st extensive use of randomized controlled trials after the 2nd World War.
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Overcoming Barriers to Clinical Trial Enrollment.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2019
Clinical trials are imperative for testing novel cancer therapies, advancing the science of cancer care, and determining the best treatment strategies to enhance outcomes for patients with cancer. However, barriers to clinical trial enrollment contribute
R. Nipp, Kessely Hong, E. Paskett
semanticscholar   +1 more source

A Randomized Clinical Trial

Case Medical Research, 2019
Conclusions: The results provide evidence of a relationship between AT and ASS, CSS, A, D in hypertensive adults, indicating that social support and mood are im-portant variables that must be evaluated when measuring adherence to treatment and seeking ...
A. Tieu   +4 more
semanticscholar   +1 more source

Clinical Trials

Neurologic Clinics, 1990
Broad guidelines for the design, implementation, analysis, and reporting of results of clinical trials are given. The use of randomization, concurrent controls, and blinding is justified. Basic principles of the design of clinical trials are outlined and include the areas of specification of the hypothesis, definition of the outcome and the logistics ...
openaire   +2 more sources

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

Journal of Clinical Oncology, 1997
PURPOSE Most patients with advanced pancreas cancer experience pain and must limit their daily activities because of tumor-related symptoms. To date, no treatment has had a significant impact on the disease.
Malcolm   +16 more
semanticscholar   +1 more source

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Science Translational Medicine, 2016
An implantable ultrasound device safely disrupts the blood-brain barrier in glioblastoma patients. A sound attack on brain tumors Brain tumors are difficult to treat with chemotherapy because the blood-brain barrier greatly limits the delivery of drugs ...
A. Carpentier   +15 more
semanticscholar   +1 more source

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