Results 211 to 220 of about 60,343,578 (236)

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Model-Informed Drug Development (MIDD) for Analgesics: Review of Applications, Regulatory Integration, and Emerging Directions. [PDF]

J Pain Res
Dahan A, Pergolizzi JV, Niesters M, Olofsen E, Raffa RB.   +4 more
europepmc   +1 more source

Beyond the <i>P</i> Value: A Systematic Framework for Interpreting Oncology Clinical Trials. [PDF]

JCO Precis Oncol
Li R, Dong X, Yao X, Chen W, An H, Li Y.
europepmc   +1 more source

FOLFOX-based transarterial infusion chemotherapy for unresectable colorectal cancer: protocol of an open-label, multicentre, randomised, controlled, phase II trial. [PDF]

BMJ Open
Wang J, Sun Y, Chen L, Wang Z, Li K, Guo Y, Yao L, Duan L, Liu Q.   +8 more
europepmc   +1 more source

Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial. [PDF]

PLoS One
Chu MHM, Lai JKM, Lee A, Wu WKK, Huang Z, Wong HMK, Ho L, Su H, Ho SSM, Xu X, Pavey W, Morgan DJR, Chan MTV, Ho KM.   +13 more
europepmc   +1 more source

Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design. [PDF]

Drug Des Devel Ther
Wei Y, Wang J, Ji Y, Shang T, Shen Y, Sun H, Cai Y.   +6 more
europepmc   +1 more source

The use of pharmacodynamic results for recommended phase II decision making in oncology clinical trials. [PDF]

Cancer Chemother Pharmacol
Kanhailal AC, Lucassen MJJ, Schutte T, Zwart W, Huitema ADR, Steeghs N.   +5 more
europepmc   +1 more source

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