Results 191 to 200 of about 2,053,087 (266)

Setting Yourself up for Success as an Early Career Investigator in Clinical Trials. [PDF]

JACC Adv
Bharadwaj AS, Reza N, Wiggins N, Rymer J, Cader FA, Mehran R.   +5 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

AI and innovation in clinical trials. [PDF]

NPJ Digit Med
Badani A, de Moraes FY, Vollmuth P, Chung C, Mansouri A.   +4 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Shaping the future of clinical trials through strategic foresight. [PDF]

Clin Trials
Lee S, McIntyre J, Robertson T, Kallsen K, Bauer M, Berardi R, Boisvert-Huneault C, Clerisme-Beaty E, Denton CP, Fakra E, Geissler J, Goldstein D, Hasegawa K, Lind M, LoRusso P, Perry K, Röhl C, Saraiva JFK, Swarup N, Szpisjak A, Flyvbjerg A.   +20 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Current landscape of clinical trials for mRNA-based therapeutics. [PDF]

Hum Vaccin Immunother
Li Q, Zeng M, Lv W, Ye J, Wu S.
europepmc   +1 more source

Analysis of trends of clinical trials for medical devices registered under Clinical Trials Registry of India. [PDF]

Perspect Clin Res
Punniyamurthy P, James J, Kala P, Manohar MM, Rani RJ.   +4 more
europepmc   +1 more source

Cancer Prevention Clinical Trials: Advances and Challenges. [PDF]

Cancers (Basel)
Francis ER, Syed FZ, Rajan A, Szabo E.
europepmc   +1 more source

Commentary: Multi-stage consent for time-sensitive clinical trials. [PDF]

Clin Trials
Karel D, Wendler D.
europepmc   +1 more source