Results 111 to 120 of about 100,822 (314)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

ReseArch with Patient and Public invOlvement: a RealisT evaluation - the RAPPORT study [PDF]

, 2015
Background Patient and public involvement (PPI) is a prerequisite for many funding bodies and NHS research ethics approval. PPI in research is defined as research carried out with or by the public rather than to, about or for them.
Abbott, Abma, All-Party Parliamentary Group, Andejeski, Armes, Astbury, Badger, Baggott, Baggott, Barber, Barber, Barber, Barbour, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Batsch, Baxter, Ben-Ari, Beresford, Bhaskar, Boivin, Boote, Boote, Boote, Boote, Brannen, Brett, Brett, Brett, British Paediatric Surveillance Unit, Broerse, Burrus, Cairncross, Caldon, Callard, Caron-Flinterman, Carter, Chalmers, Clark, Clavier, Collaboration for Leadership in Applied Health Research and Care, Collier, Connelly, Connelly, Consumers Health Forum of Australia, Cotterell, Cotterell, Cystic Fibrosis Trust, Davis, Davis, Delanty, Delbanco, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Dewar, Edwards, Elberse, Entwistle, Entwistle, Evans, Expert Patients Programme, Exworthy, Fairbrother, Faulkner, Fiss, Forbat, Forbes, Fulop, Gibson, Goodman, Goodman, Gradinger, Great Britain, Greene, Guarino, Habermas, Habermas, Habermas, Hartley, Hawe, Hayes, Held, Hewitt, Hewlett, Higher Education Funding Council for England, HM Government, HM Government, Hofmann, Howe, Howe, Hunn, Hunt, Iliffe, INVOLVE, INVOLVE, Ives, Jagosh, Jagosh, Jordan, Kontos, Koops, Kreindler, Kreis, Krieger, Langston, Lasker, Lindenmeyer, Lupton, Macaulay, Marchal, Marinetto, Martin, Martin, Mathie, Matthews, May, May, May, May, McCormick, McDonnell, McGrath, McKevitt, McKevitt, McNichol, Medical Research Council, Merton, Meyer, Middleton, Miller, Milton, Minogue, Morrow, Nathan, National Cancer Research Institute, National Institute of Health Research, National Institutes of Health, National Voices, Ocloo, Oliver, Oliver, Oliver, Oliver, O’Cathain, O’Donnell, Palmer, Parkes, Paterson, Patient and Public Involvement Solutions, Pattengill-Semmens, Pawson, Pawson, Pawson, Peckham, Philpot, PiiAF Study Group, Pitt, Prior, Purttell, Renedo, Research Design Service London, Rhodes, Roderick, Royal College of Psychiatry, Royle, Rycroft-Malone, Rycroft-Malone, Savage, Schierhout, Schneider, Schwappach, Scott, Shippee, Shirk, Smith, Snape, Staley, Staley, Staley, Staley, Staniszewska, Staniszewska, Staniszewska, Staniszewska, Staniszewska, Stevens, Strauss, Sutton, Telford, Telford, Terry, Thompson, Thompson, Thompson, Titmuss, Tolson, Tritter, Truman, Vale, van Bekkum, Walker, Wand, Ward, Williams, Williams, Williamson, Wilson, Wilson, Wilson, Wilson, World Health Organization, Wright, Yin   +225 more
core   +4 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Mechanism-based modular psychotherapy versus cognitive behavioural therapy for adolescents and young adults with childhood trauma experiences: study protocol for a feasibility trial within the German Center for Mental Health

BMJ Open
Introduction Patients with mental disorders and a history of childhood trauma show an early onset of psychopathology and often a poor response to standard disorder-specific treatments.
Till Bärnighausen, Hanna Zimmermann, Christian Schmahl, Stephanie Bauer, Beate Ditzen, Hans-Christoph Friederich, Markus W Haun, Astrid Berner-Rodoreda, Elisabeth Schramm, Svenja Taubner, Corina Aguilar-Raab, Sabine C Herpertz, Manuel Feisst, Frank Enning, Katja I Seitz, Niklas Schouler, Jan Hundertmark, Maximilian Wilhelm, Svea Franz, Christoph W Korn, Ruben Vonderlin, Eva Vonderlin, Josef Bailer, Elias Bopp, Sophia von Stockert, Laura Tabea Kristalis, Claudia Calvano   +26 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study [PDF]

, 2017
Introduction: The rapid worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) constitutes a major challenge. The aim of the EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA), which is part
Bravo Ferrer, José, Gutiérrez Gutiérrez, Belén, Pascual Hernández, Álvaro (Coordinador), Rodriguez Baño, Jesus, Sojo Dorado, Jesús   +4 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Design of an international, phase IV, open-label study of simoctocog alfa in women/girls with hemophilia A undergoing surgery (NuDIMENSION)

Therapeutic Advances in Hematology
Background: Although hemophilia A mainly affects males, carriers (defined as females with hemophilia A, as well as symptomatic or asymptomatic hemophilia A carriers) are at risk of excessive bleeding, particularly during trauma or during surgical ...
Natascha Marquardt, Florian Langer, Katharina Holstein, María Teresa Álvarez Román, Ramiro Núñez Vázquez, Predrag Miljić, Nicolas Drillaud, Laurent Ardillon, Anna-Elina Lehtinen, Rita Carlotta Santoro, Mariasanta Napolitano, Sergio Siragusa, Gillian Gidley, Martina Jansen, Sigurd Knaub, Johannes Oldenburg   +15 more
doaj   +1 more source