Results 221 to 230 of about 41,480 (249)

Decision Analysis for a Data Monitoring Committee of a Clinical Trial

1998
A data monitoring committee holds a position of great trust within the structure of a US clinical trial, as it alone receives the accumulating data and decides whether to continue the trial. The committee generally meets at regularly scheduled intervals, e.g. six months.
Joseph B. Kadane, Pantelis Vlachos, Samuel Wieand   +2 more
openaire   +1 more source

Coordinating Data Monitoring Committees and Adaptive Clinical Trial Designs

Drug Information Journal, 2008
There is a growing interest in employing adaptive clinical trial designs in drug development. Adaptation is usually based on accumulative efficacy data alone. This article examines issues that can arise when an independent data monitoring committee must interface their safety concerns when adaptive changes based on efficacy are taking place.
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Data monitoring committees and randomized clinical trials

Kidney International, 2019
Howard, Trachtman, Arthur L, Caplan
openaire   +2 more sources

Data monitoring committees in clinical trials: best practice, complexities and considerations

Clinical Investigation, 2015
What is the problem all about? Clinical trials are sometimes described as being rather ‘blunt’ instruments, and that often may be true: we use them to find answers to very broad questions such as ‘does this drug work better than a control drug?’ But they are also very important and delicate instruments: we use them to find answers to questions such as ‘
openaire   +1 more source

Clinical Trials of Herpes Simplex Encephalitis: The Role of the Data Monitoring Committee

2006
Herpes simplex encephalitis (HSE) is the most frequent cause of focal necrotizing encephalitis, accounting for approximately 2,500 cases annually in the United States. Studies initiated in the early 1970s have continuously evaluated promising antiviral drugs for the treatment of this disease, utilizing randomized, blinded, controlled clinical trial ...
openaire   +1 more source

Data Monitoring Committees in Clinical Trials: A Practical Perspective

The American Statistician, 2022
openaire   +1 more source

Data Monitoring Committees in Clinical Trials

Journal of the Royal Statistical Society: Series D (The Statistician), 2003
openaire   +1 more source

Data Monitoring Committees in Clinical Trials

2019
Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets   +2 more
openaire   +1 more source

Data and Safety Monitoring Committees in Clinical Trials

2009
Jay Herson, Jay Herson
openaire   +1 more source

FDA and Clinical Trial Data Monitoring Committees

2006
Susan S. Ellenberg, Jay P. Siegel
openaire   +1 more source