Results 91 to 100 of about 10,563 (168)

Clinical trial of tolerability, safety and immunogenicity of influenza inactivated split-vaccine Flu-M in children aged 6 to 17 years

Журнал инфектологии
Purpose. To evaluate the tolerability, safety and immunogenicity of influenza inactivated split flu vaccine Flu-M during single immunization of children aged 6 to 17 years.Materials and methods.
A. M. Korolyuk, V. N. Kraeva, L. A. Zazimko, Yu. A. Koromzin, E. A. Ruzanova, N. N. Savina, E. V. Ryskova   +6 more
doaj   +1 more source

A phase 1/2, open-label study evaluating twice-daily administration of momelotinib in myelofibrosis

Haematologica, 2017
Momelotinib, a small-molecule inhibitor of Janus kinase 1 and Janus kinase 2, has demonstrated efficacy in myelofibrosis patients with 300 mg, once-daily dosing.
Vikas Gupta, Ruben A. Mesa, Michael W.N. Deininger, Candido E. Rivera, Shireen Sirhan, Carrie Baker Brachmann, Helen Collins, Jun Kawashima, Yan Xin, Srdan Verstovsek   +9 more
doaj   +1 more source

The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis

Haematologica, 2020
Approximately 20-50% patients with chronic phase chronic myeloid leukemia (CML-CP) treated with tyrosine kinase inhibitors (TKI) or with myelofibrosis (MF) treated with ruxolitinib develop grade ≥3 thrombocytopenia needing treatment interruptions and ...
Mahran Shoukier, Gautam Borthakur, Elias Jabbour, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Jairo Matthews, Lucia Masarova, Kiran Naqvi, Koji Sasaki, Srdan Verstovsek, Jorge Cortes   +11 more
doaj   +1 more source

How Psychiatry Journals Support the Unbiased Translation of Clinical Research. A Cross-Sectional Study of Editorial Policies [PDF]

, 2013
Introduction: Reporting guidelines (e. g. CONSORT) have been developed as tools to improve quality and reduce bias in reporting research findings. Trial registration has been recommended for countering selective publication.
Knüppel, Hannes, Meerpohl, Jörg J., Metz, Courtney, Strech, Daniel   +3 more
core   +3 more sources

One‐Year Quality of Life Among Survivors of Hospitalization for Omicron Infection in Brazil: A Multicentre Prospective Cohort Study

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT The lingering effects of COVID‐19 may impair survivors' long‐term health‐related quality of life (HRQoL). However, multicentre studies focusing on the Omicron variant, particularly in middle‐ and low‐income settings, are scarce. We conducted a prospective cohort study across 24 Brazilian hospitals between December 2021 and March 2024, when ...
Geraldine Trott, Marciane Maria Rover, Fernando Luis Scolari, Mariana Motta Dias da Silva, Denise de Souza, Rosa da Rosa Minho dos Santos, Raíne Fogliati De Carli, Emelyn de Souza Roldão, Gabriela Soares Rech, Duane Mocellin, Jennifer Menna Barreto de Souza, Aline Paula Miozzo, Carolina Rothmann Itaqui, Gabrielle Nunes da Silva, Sergio Renato da Rosa Decker, Erica Neves Leite, Carlos Delmar do Amaral Ferreira, Lucas Gobetti da Luz, Gabriel Beilfuss Rieth, Lucas Tramujas, Fernando Azevedo Medrado, Bruna Fornazieri Piotto, Gizelle Fernanda Oliveira Silva, Josafá Ferreira Chaves, Saionara Cristina Francisco, Precil Diego Miranda de Menezes Neves, Victor Augusto Hamamoto Sato, Viviane Cordeiro Veiga, Kaique Lima Martins, Cláudio Dornas de Oliveira, Sabrina Gomes dos Santos, Juliana Cardozo Fernandes, Thiago Costa Lisboa, Vivian Menezes Irineu, Mauricio Antonio Pompilio, Adriana de Oliveira França, Aline Coletto Jaccottet, Juliana Carvalho Schleder, Vinicius Ortigosa Nogueira, Vandack Nobre, Daniel Souto Silveira, Cézar Eumann Mesas, Diego Miltersteiner, Emanuelle Toledo Ortiz, Fernando Gioppo Blauth, Luciane Maria Facchi, Milena Soriano Marcolino, Ana Carolina Peçanha Antonio, Paulo R. Schvartzman, Bruna Brandão Barreto, Caroline Cabral Robinson, Maicon Falavigna, Carisi Anne Polanczyk, Luiz Antonio Nasi, Regis Goulart Rosa, Post‐Covid Brasil 1 Group Autorship   +55 more
wiley   +1 more source

Implementation of Metformin Therapy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD): study protocol for a phase III, multi-centre, randomized, placebo-controlled trial evaluating the long-term efficacy of metformin in slowing the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease

Trials
Background Autosomal dominant polycystic kidney disease (ADPKD) is the fourth most common reason for commencement of dialysis globally. There is an urgent need for treatments to slow the loss of kidney function and prevent complications in people with ...
Kitty St Pierre, Ragada El-Damanawi, David W. Johnson, Carmel M. Hawley, Andrea K. Viecelli, Vivekanand Jha, Suetonia C. Green, Loreto Gesualdo, Charani Kiriwandeniya, Pushparaj Velayudham, Liza A. Vergara, Gabor Mihala, Misa Matsuyama, Peta-Ann Paul Brent, Andrew J. Mallett, IMPEDE-PKD Global Steering Committee (see Appendix)   +15 more
doaj   +1 more source

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study [PDF]

, 2019
Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment.
Allegretti, M., Ferrari, M., Garhoefer, G., Lambiase, A., Mantelli, F., Sacchetti, M., Schmetterer, L., Schmidl, D.   +7 more
core   +1 more source

Patterns of Adherence to Lung Volume Recruitment Therapy Amongst Individuals With Duchenne Muscular Dystrophy: A Secondary Analysis of the STEADFAST Randomized Controlled Trial

Pediatric Pulmonology, Volume 60, Issue 10, October 2025.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is associated with impaired airway clearance and chest wall restriction, treated with lung volume recruitment (LVR) therapy. This study evaluated adherence patterns to LVR over 2 years in a cohort of boys with DMD.
Naomi Dussah, Douglas A. McKim, Jean K. Mah, Hugh J. McMillan, Craig Campbell, Vid Bijelić, Nicholas Barrowman, Franco Momoli, Henrietta Blinder, Shawn Aaron, Laura C. McAdam, The Thanh Diem Nguyen, Mark Tarnopolsky, David Wensley, David Zielinski, Lisa Wolfe, Sherri L Katz   +16 more
wiley   +1 more source

A systematic review of the evidence on home care reablement services [PDF]

, 2015
Objective To determine whether publically funded ‘reablement services’ have any effect on patient health or use of services. Design Systematic review of randomised controlled trials and non-randomized studies in which reablement interventions were ...
Alex Davidson, Avril Drummond, Blase K, Bonner CD, Care Services Efficiency Delivery (CSED) Programme, Care Services Efficiency Delivery (CSED) Programme, Department of Health, Department of Health, Forder J, Gershon Sir Peter, Ghatorae H, Glendinning C, HM Government Office for Disability Issues, Joffe J, John Gladman, Jones K, Kent J, Legg L, Lewin G, Lynn Legg, McLeod B, Medical Research Council (MRC), Newbronner L, Rabiee P, Rabiee P, Shepperd S, Shepperd S   +26 more
core   +2 more sources

Selective carious tissue removal using subjective criteria or polymer bur: study protocol for a randomised controlled trial (SelecCT) [PDF]

, 2018
Introduction: Selective (incomplete/partial) carious tissue removal is suitable for treating deep carious lesions in teeth with vital, asymptomatic pulps.
Dias Ribeiro, Ana Paula, Gomes Marques, Marta, Hilgert, Leandro Augusto, Leal, Soraya, Paris, Sebastian, Schlattmann, Peter, Schwendicke, Falk   +6 more
core   +1 more source