Haematologica, 2021 Chemoimmunotherapy with fludarabine, cyclophosphamide and rituximab (FCR) can induce long-term remissions in patients with chronic lymphocytic leukemia.
Johannes Bloehdorn +15 more
doaj +1 more source
Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib [PDF]
, 2017 Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete
Dumrese, Claudia +28 more
core +4 more sources
Long term post PrePex male circumcision outcomes in an urban population in Uganda: a cohort study
BMC Research Notes, 2017 Objective The objective of this study was to determine the long term adverse events profile at least a year after safe male circumcision. Results A cohort study, investigating patients who had undergone a non surgical circumcision procedure called Prepex.
M. Galukande +5 more
doaj +1 more source
Learning curve for minimally invasive oesophagectomy of oesophageal cancer and survival analysis
Journal of Cardiothoracic Surgery, 2021 Purpose Minimally invasive oesophagectomy is a technically demanding procedure, and the learning curve for this procedure should be explored. A survival analysis should also be performed.
Yunpeng Zhao +4 more
doaj +1 more source
The impact of approaches in improving male partner involvement in the prevention of mother-to-child transmission of HIV on the uptake of maternal antiretroviral therapy among HIV-seropositive pregnant women in sub-Saharan Africa: a systematic review and meta-analysis. [PDF]
, 2017 Objectives: To identify the approaches that are used in improving on male partner involvement in the prevention of mother-to-child transmission (PMTCT) of HIV and their impact on the uptake maternal antiretroviral therapy (ART) in sub-Saharan Africa (SSA)
Johnman, Cathy +2 more
core +1 more source
Quality and Publication of Emergency Medicine Trials Registered in ClinicalTrials.gov [PDF]
, 2020 Introduction: Promoting emergency medicine (EM) clinical trials research remains a priority. To characterize the status of clinical EM research, this study assessed trial quality, funding source, and publication of EM clinical trials and compared EM and ...
Calvocoressi, Lisa +7 more
core
Trial discontinuation: lessons for future trial design? [PDF]
, 2012 Background: The current therapeutic arsenal still does not fulfill the therapeutic needs of inflammatory bowel disease patients. Although new drugs are constantly being developed, many will never reach the market.
Haar, C.J. (Colin) de +2 more
core +1 more source
Haematologica, 2023 Chemoimmunotherapy followed by consolidative high-dose therapy with autologous stem cell rescue was a standard upfront treatment for fit patients with mantle cell lymphoma (MCL) in first remission; however, treatment paradigms are evolving in the era of
Zachary D. Epstein-Peterson +23 more
doaj +1 more source
Protocol for a systematic scoping review of reasons given to justify the performance of randomised controlled trials. [PDF]
, 2019 IntroductionRandomised controlled trials (RCTs) are widely viewed to generate the most reliable medical knowledge. However, RCTs are not always scientifically necessary and therefore not always ethical.
Chevrier, Stephanie +7 more
core +2 more sources
Study protocol for THINK : a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types [PDF]
, 2017 Introduction: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3 zeta signalling domain, which associates with the adaptor ...
Aftimos, Philippe +15 more
core +1 more source