Results 41 to 50 of about 10,015 (184)

Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib [PDF]

, 2017
Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete
Dumrese, Claudia, Ferrant, Augustin, Gavasso, Sonia, Gedde-Dahl, Tobias, Giles, Francis, Gjertsen, Bjorn Tore, Gullaksen, Stein-Erik, Hellmann, Andrzej, Hjorth-Hansen, Henrik, Hochhaus, Andreas, Janssen, Jeroen, Labar, Boris, Lang, Alois, Majeed, Waleed, Mihaylov, Georgi, Mustjoki, Satu, Ossenkoppele, Gert, Porkka, Kimmo, Skavland, Jorn, Sopper, Sieghart, Stenke, Leif, Stentoft, Jesper, Thaler, Josef, Thielen, Noortje, Tosevski, Vinko, Verhoef, Gregor, Voglova, Jaroslava, Warzocha, Krzysztof, Wolf, Dominik   +28 more
core   +4 more sources

Oral HDAC inhibitor tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: phase IIb results

Haematologica, 2022
Tucidinostat (formerly known as chidamide) is an orally available, novel benzamide class of histone deacetylase (HDAC) inhibitor that selectively blocks class I and class IIb HDAC.
Shinya Rai, Won Seog Kim, Kiyoshi Ando, Ilseung Choi, Koji Izutsu, Norifumi Tsukamoto, Masahiro Yokoyama, Kunihiro Tsukasaki, Junya Kuroda, Jun Ando, Michihiro Hidaka, Youngil Koh, Hirohiko Shibayama, Toshiki Uchida, Deok Hwan Yang, Kenji Ishitsuka, Kenichi Ishizawa, Jin Seok Kim, Hong Ghi Lee, Hironobu Minami, Hyeon Seok Eom, Mitsutoshi Kurosawa, Jae Hoon Lee, Jong Seok Lee, Won Sik Lee, Hirokazu Nagai, Takero Shindo, Dok Hyun Yoon, Shinichiro Yoshida, Mireille Gillings, Hiroshi Onogi, Kensei Tobinai   +31 more
doaj   +1 more source

The impact of approaches in improving male partner involvement in the prevention of mother-to-child transmission of HIV on the uptake of maternal antiretroviral therapy among HIV-seropositive pregnant women in sub-Saharan Africa: a systematic review and meta-analysis. [PDF]

, 2017
Objectives: To identify the approaches that are used in improving on male partner involvement in the prevention of mother-to-child transmission (PMTCT) of HIV and their impact on the uptake maternal antiretroviral therapy (ART) in sub-Saharan Africa (SSA)
Johnman, Cathy, Kennedy, Iain T.R., Takah, Noah F.   +2 more
core   +1 more source

Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization

Haematologica, 2023
Warm autoimmune hemolytic anemia (wAIHA) is a rare acquired autoimmune disease mediated by antibodies targeting red blood cells. The involvement of CD4 T-helper cells has been scarcely explored, with most findings extrapolated from animal models.
Marion Ciudad, Sethi Ouandji, Baptiste Lamarthée, Claudie Cladière, Thibault Ghesquière, Martin Nivet, Marine Thébault, Romain Boidot, Agnès Soudry-Faure, Sandy Chevrier, Corentin Richard, Thibault Maillet, François Maurier, Hélène Greigert, Coraline Genet, André Ramon, Malika Trad, Valérie Predan, Philippe Saas, Maxime Samson, Bernard Bonnotte, Sylvain Audia   +21 more
doaj   +1 more source

Protocol for a systematic scoping review of reasons given to justify the performance of randomised controlled trials. [PDF]

, 2019
IntroductionRandomised controlled trials (RCTs) are widely viewed to generate the most reliable medical knowledge. However, RCTs are not always scientifically necessary and therefore not always ethical.
Chevrier, Stephanie, Dewar, Brian, Fedyk, Mark, Jurkovic, Lucas, Kitto, Simon C, Rodriguez, Rosendo, Saginur, Raphael, Shamy, Michel   +7 more
core   +2 more sources

Herbal medicines (Eunkyosan and Samsoeum) for treating the common cold: a protocol for a randomized, placebo-controlled, multicenter clinical trial

Integrative Medicine Research, 2020
Background: The common cold is the most frequent acute respiratory illness that places a burden on society, both personally and economically. There is no standard therapy; only symptomatic therapy remains the mainstay of common cold treatment.
Kwan-Il Kim, Minna Hong, Yang-Chun Park, Beom-Joon Lee, Kitae Kim, Byung Kab Kang, Jun-Yong Choi   +6 more
doaj   +1 more source

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment

Haematologica, 2023
Metabolomics studies in sickle cell disease (SCD) have been so far limited to tens of samples, owing to technical and experimental limitations. To overcome these limitations, we performed plasma metabolomics analyses on 596 samples from patients with ...
Angelo D’Alessandro, S. Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Julie A. Reisz, Xu Zhang, Kyle W. Bartsch, Matthew D. Galbraith, Joaquin M. Espinosa, Victor R. Gordeuk, Mark T. Gladwin   +11 more
doaj   +1 more source

Clinical Evaluation of Risankizumab-rzaa in the Treatment of Plaque Psoriasis. [PDF]

, 2020
Risankizumab-rzaa (Skyrizi®; AbbVie) is a humanized IgG monoclonal antibody directed against interleukin-23p19 (IL-23p19) indicated for the treatment of moderate-to-severe psoriasis in adults who are candidates for systemic therapy or phototherapy.
Liao, Wilson, Myers, Bridget, Reddy, Vidhatha, Yang, Eric J   +3 more
core   +1 more source

A Paleolithic Diet with and without Combined Aerobic and Resistance Exercise Increases Functional Brain Responses and Hippocampal Volume in Subjects with Type 2 Diabetes

Frontiers in Aging Neuroscience, 2017
Type 2 diabetes is associated with impaired episodic memory functions and increased risk of different dementing disorders. Diet and exercise may potentially reverse these impairments.
Andreas Stomby, Andreas Stomby, Julia Otten, Mats Ryberg, Lars Nyberg, Lars Nyberg, Lars Nyberg, Tommy Olsson, Carl-Johan Boraxbekk, Carl-Johan Boraxbekk, Carl-Johan Boraxbekk   +10 more
doaj   +1 more source

Different doses of dual orexin receptor antagonists in primary insomnia: a Bayesian network analysis

Frontiers in Pharmacology, 2023
Background: Systematic comparisons of the doses of the Food and Drug Administration (FDA)-approved dual orexin receptor antagonists (DORAs) for people with insomnia are limited.Methods: PubMed, Embase, Cochrane Library, and Clinicaltrials.
Tao Xue, Xin Wu, Xin Wu, Jiaxuan Li, Shujun Chen, Zilan Wang, Xin Tan, Zhong Wang, Jianguo Zhang, Jianguo Zhang, Jianguo Zhang   +10 more
doaj   +1 more source