Results 61 to 70 of about 10,563 (168)

Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization

Haematologica, 2023
Warm autoimmune hemolytic anemia (wAIHA) is a rare acquired autoimmune disease mediated by antibodies targeting red blood cells. The involvement of CD4 T-helper cells has been scarcely explored, with most findings extrapolated from animal models.
Marion Ciudad, Sethi Ouandji, Baptiste Lamarthée, Claudie Cladière, Thibault Ghesquière, Martin Nivet, Marine Thébault, Romain Boidot, Agnès Soudry-Faure, Sandy Chevrier, Corentin Richard, Thibault Maillet, François Maurier, Hélène Greigert, Coraline Genet, André Ramon, Malika Trad, Valérie Predan, Philippe Saas, Maxime Samson, Bernard Bonnotte, Sylvain Audia   +21 more
doaj   +1 more source

Sex differences in the associations between L-arginine pathway metabolites, skeletal muscle mass and function, and their responses to resistance exercise, in old age [PDF]

, 2017
This work was supported by the Biotechnology and Biological Sciences Research Council (BB/J015911/1) and was registered at clinicaltrials.gov (ClinicalTrials. gov Identifier: NCT02843009).
A. A. Mangoni, A. Zinellu, A.A. Mangoni, A.S. Levey, B. Roshanravan, C. Carru, C. Moali, C. Wadham, C.P. Jenkinson, D. Atzler, D. Elliot, H.D. Hoberman, I. Janssen, J. R. Meakin, J.L. O’Loughlin, J.S. Stamler, K. Obayashi, K.L. Timmerman, L. Campins, L. Viinikka, M. da Boit, M. Davids, M.C. Devries, M.D. Peterson, M.E. Cullen, M.J. Delmonico, O.S. Bentur, P. Vallance, R. M. Aspden, R. Sibson, R.B. Caldwell, R.N. Baumgartner, R.R. Kalyani, S. Pilz, S. Sotgia, S. Tommasi, Stuart R. Gray, T. Michel, W.K. Mitchell   +38 more
core   +3 more sources

Integration of a WASH Component in the Standard National Protocol for Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months in Northern Senegal—A Costing Study

Maternal &Child Nutrition, Volume 22, Issue 1, March 2026.
This study provides the first cost analysis of integrating a WASH kit into outpatient SAM treatment in Senegal, highlighting key cost drivers and potential efficiencies for scale‐up. Findings offer practical insights for planning and budgeting integrated WASH‐nutrition interventions in similar settings.
Bibata Wassonguema, Maily Lê‐Lacanette, Laura Braun, Matar Ba, Françoise Siroma, Albert Emile Cabo, Antonio Vargas Brizuela, Moustapha Seye, Jean Lapègue, Alexandre Devort, Oliver Cumming, Dieynaba S. N'Diaye   +11 more
wiley   +1 more source

BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors

npj Precision Oncology
Aberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng, Hong Chen, Bang Fu, Hongming Pan, Jiabing Wang, Weidong Han   +5 more
doaj   +1 more source

Arsenic trioxide versus Realgar-Indigo naturalis formula in non-high-risk acute promyelocytic leukemia: a multicenter, randomized trial

Haematologica
Realgar-Indigo Naturalis Formula (RIF) is an oral form of arsenic that is effective against acute promyelocytic leukemia (APL). This multicenter, randomized, controlled trial compared the efficacy of all-trans retinoic acid (ATRA) plus RIF with ATRA ...
Shu Chen, Weiwei Qin, Xiaohong Lu, Li Liu, Yinsuo Zheng, Xinhua Lu, Xiaohui Wang, Xiaojuan Zhang, Sha Gong, Suhua Wei, Huiyun Zhang, Hanru Ding, Ranjbarha Seifollah, Jing Li, Haitao Zhang, Di Wu, Olubukola Abiona, Pengcheng He, Rong Zhang, David Wald, Huaiyu Wang   +20 more
doaj   +1 more source

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment

Haematologica, 2023
Metabolomics studies in sickle cell disease (SCD) have been so far limited to tens of samples, owing to technical and experimental limitations. To overcome these limitations, we performed plasma metabolomics analyses on 596 samples from patients with ...
Angelo D’Alessandro, S. Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Julie A. Reisz, Xu Zhang, Kyle W. Bartsch, Matthew D. Galbraith, Joaquin M. Espinosa, Victor R. Gordeuk, Mark T. Gladwin   +11 more
doaj   +1 more source

Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department [PDF]

, 2020
As of March 30th, 2020 there were 161,807 total cases and 2,953 total deaths of SARS-CoV-2 in the United States, with the number of cases expected to rise.
Brown, Cortlyn, Coralic, Zlatan, Noble, Jeanne   +2 more
core  

Influence of frailty in older patients undergoing emergency laparotomy: a UK-based observational study [PDF]

, 2017
Introduction The National Emergency Laparotomy Audit (NELA) has reported that older patients (≥65 years) form a large percentage of emergency high-risk cases with increased postoperative morbidity and mortality.
Farrell, Ian, Hewitt, Jonathan, Moug, Susan, Parmar, Kat L, Pearce, Lyndsay   +4 more
core   +1 more source

Efficacy and Safety of Butylphthalide for Neurological Recovery After Cardiac Arrest: A Pilot Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Butylphthalide (NBP) is a neuroprotective agent that ameliorates cerebral ischemia‐hypoxia and reperfusion injury. However, evidence regarding whether NBP can improve neurological prognosis in patients with cardiac arrest (CA) remains limited.
Xingsheng Wang, Rui Shao, Chenchen Hang, Weijie Cheng, Zihao Jiang, Ziqi Zhong, Le An, Tao Wang, Ziren Tang   +8 more
wiley   +1 more source

Development and validation of a pathomics model for accurate grading of pancreatic neuroendocrine tumors

npj Precision Oncology
Accurate detection of the histological grade of pancreatic neuroendocrine tumors (PanNETs) is important for patients’ prognoses and treatment. Traditional grading methods based on mitotic count and Ki-67 index are subjective and time-consuming.
Ying Li, Chengwei Chen, Yunshuo Zhang, Jieyu Yu, Xu Fang, Fang Liu, Tiegong Wang, Jing Li, Li Wang, Jianping Lu, Hui Jiang, Chengwei Shao, Yun Bian   +12 more
doaj   +1 more source