Results 71 to 80 of about 10,563 (168)

Different doses of dual orexin receptor antagonists in primary insomnia: a Bayesian network analysis

Frontiers in Pharmacology, 2023
Background: Systematic comparisons of the doses of the Food and Drug Administration (FDA)-approved dual orexin receptor antagonists (DORAs) for people with insomnia are limited.Methods: PubMed, Embase, Cochrane Library, and Clinicaltrials.
Tao Xue, Xin Wu, Xin Wu, Jiaxuan Li, Shujun Chen, Zilan Wang, Xin Tan, Zhong Wang, Jianguo Zhang, Jianguo Zhang, Jianguo Zhang   +10 more
doaj   +1 more source

Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system : study protocol for a stepped-wedge randomized trial [PDF]

, 2017
Background: There is robust clinical evidence to support offering early access to antiretroviral treatment (ART) to all HIV-positive individuals, irrespective of disease stage, to both improve patient health outcomes and reduce HIV incidence. However, as
Barnighausen, Till, Delva, Wim, Fleming, Yvette, Khumalo, Gavin, Lejeune, Charlotte L, Mazibuko, Sikhathele, Mlambo, Charmaine Khudzie, Okello, Velephi, Reis, Ria, Spiegelman, Donna, Walsh, Fiona J, Zwane, Mandisa   +11 more
core   +5 more sources

Rationale and Design of the PASSIVATE‐CAP Trial: The Preventive Intervention Value of Drug‐Coated Balloons in Vulnerable Coronary Atherosclerotic Plaques

Clinical Cardiology, Volume 49, Issue 1, January 2026.
PASSIVATE‐CAP Research Overview and Flowchart. ABSTRACT Background Patients with acute coronary syndrome (ACS) face a significantly increased risk of cardiovascular events due to vulnerable plaques. However, no clear evidence supports performing preventive percutaneous coronary intervention (PCI) for non‐flow‐limiting vulnerable plaques.
Zhongxiu Chen, Junyan Zhang, Minggang Zhou, Shichu Liang, Yong Chen, Chen Li, Hua Wang, Jiafu Wei, Baotao Huang, Mian Wang, Yong He, for the PASSIVATE‐CAP trial investigator   +11 more
wiley   +1 more source

Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Primary dysmenorrhea is a prevalent condition that causes significant menstrual pain and discomfort, impacting many women′s daily activities. The Substance P/NK1 receptor (SP/NK1R) pathway has been linked to the pain mechanisms underlying dysmenorrhea, yet its potential as a therapeutic target remains inadequately explored.
Riffat Mehboob, Imran Shahid, Abdullah R. Alzahrani, Shimaa Mohammad Yousof, Hafsa Adnan, Samar N. Ekram, Ahmad Alwazzan, Hisham Nasief, Khalid A. Khadawardi   +8 more
wiley   +1 more source

Post‐trial access to antiretrovirals: Who owes what to whom? [PDF]

, 2011
Many recent articles argue that participants who seroconvert during HIV prevention trials deserve treatment when they develop AIDS, and there is a general consensus that the participants in HIV/AIDS treatment trials should have continuing post‐trial ...
Millum, Joseph
core   +2 more sources

Retrospective case‐control study of nutritional and respiratory status in children with type III esophageal atresia

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 1, Page 184-193, January 2026.
Abstract Objectives To evaluate the impact of undernutrition in school‐aged children born with type III esophageal atresia (EA), and to determine its potential risk factors, including their respiratory history and status assessed by pulmonary function tests at school‐age. Methods Retrospective multicentre cohort study encompassing patients born between
Marie‐Alix Chansou, Rony Sfeir, Arnaud Bonnard, Véronique Rousseau, Thomas Gelas, Audrey Guinot, Edouard Habonimana, Pascale Micheau, Aline Ranke, Isabelle Talon, Sabine Irtan, Thierry Lamireau, Pierre‐Yves Rabattu, Frédéric Elbaz, Nicolas Kalfa, Nicoleta Panait, Virginie Fouquet, Hubert Lardy, Aurélien Scalabre, Philippe Buisson, Marc Margaryan, Frédéric Auber, Céline Grosos, Corinne Borderon, Cécilia Tölg, Jeanne Goulin, Guillaume Podevin, Frédéric Gottrand, Françoise Schmitt   +28 more
wiley   +1 more source

Effect of emotional content on online video sharing among health care professionals and researchers (DIFFUSION): results and lessons learnt from a randomised controlled trial. [PDF]

, 2018
OBJECTIVES: We assessed the effect of emotional content on the extent to which online videos are shared among health professionals. SETTING: We conducted a two-arm randomised controlled trial.
Edwards, Phil, Kiriya, Junko, Roberts, Ian   +2 more
core   +1 more source

Comparison of the Efficacy and Safety of Sutureless Technique Versus Conventional Surgery in the Initial Treatment of Total Anomalous Pulmonary Venous Connection: A Systematic Review and Meta‐Analysis

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Total anomalous pulmonary venous connection (TAPVC) is a rare but life‐threatening congenital heart defect that requires surgical correction. The sutureless technique has been developed as an alternative to conventional repair to minimize postoperative complications.
Lei Shen, Nan Ding, Haiju Liu, Hanlu Yi, Jinrui Zhang, Gejingwa Zhao, Zhiqiang Li   +6 more
wiley   +1 more source

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

Butyrate‐Mediated Upregulation of Insulin Pathway Gene Expression Suggests Potential Antidiabetic Effects

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Type 2 diabetes (T2D) is a major cause of morbidity in developed countries and involves insulin resistance, a failure to correctly respond to insulin. Numerous studies in rodent T2D models suggested that the short‐chain fatty acid butyrate, produced by gut microbiota species through fermentation of dietary fibers, improves T2D symptoms.
Elad Shapira, Irena Voinsky, Hana Klin, David Gurwitz   +3 more
wiley   +1 more source