Results 91 to 100 of about 1,880,045 (291)

Management of mental health disorders in HIV-positive patients

Southern African Journal of HIV Medicine, 2013
These guidelines are intended as a reference document to assist HIV nurse and doctor clinicians in managing mental health disorders. It is intended to improve awareness, knowledge and capacity to support patients living with HIV and mental health ...
Southern African HIV Clinicians Society
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

“It’s a matter of building bridges…” – feasibility of a carer involvement intervention for inpatients with severe mental illness [PDF]

, 2019
Background Family and friends (carer) involvement in the treatment of people with mental illness is widely recommended. However, the implementation remains poor, especially during hospital treatment, where carers report being excluded from care ...
Conneely, Maev, Giacco, Domenico, Kaselionyte, Justina   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Editorial

Southern African Journal of HIV Medicine, 2002
No abstract available.
Des Martin
doaj   +1 more source

Cues and knowledge structures used by mental-health professionals when making risk assessments [PDF]

, 2008
Background: Research into mental-health risks has tended to focus on epidemiological approaches and to consider pieces of evidence in isolation. Less is known about the particular factors and their patterns of occurrence that influence clinicians’ risk ...
Ann Adams, Bouch J., Buckingham C. D, Buckingham C. D., Buzan T, Carter G., Castle K., Chris Mace, Christopher D. Buckingham, Dick P., Doctor R, Hanson R. K, Harris E. C., Higgins N., Holdsworth N., Maden A, Mays N., Monahan J., Morgan H. G., Morgan H. G., Muehlenkamp J. J, Neuendorf K, Owens D., Ryan T, Skegg K, Stengel E, Szmukler G, Watts D.   +27 more
core   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Guidelines for renal replacement therapy in HIV-infected individuals in South Africa

Southern African Journal of HIV Medicine, 2008
No abstract available.
Editorial Office
doaj   +1 more source

The development of facility standards for common outpatient procedures and implications for the context of abortion. [PDF]

, 2018
BackgroundIn recent years, an increasing number of states have enacted laws that impose specific requirements for facilities in which abortions are performed.
Berglas, Nancy F, Roberts, Sarah CM
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source